BDBM295751 N-(4-(5-((4-Chloro-1H-indazol-5-yl)amino)-1,3,4-thiadiazol-2-yl)pyridin-2-yl)-2-(4-fluorophenyl)propanamide::US10112935, Example 34

SMILES CC(C(=O)Nc1cc(ccn1)-c1nnc(Nc2ccc3[nH]ncc3c2Cl)s1)c1ccc(F)cc1

InChI Key InChIKey=QQECLIMOLAXRPT-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 295751   

TargetRho-associated protein kinase 1(Human)
Lycera

US Patent
LigandPNGBDBM295751(US10112935, Example 34 | N-(4-(5-((4-Chloro-1H-ind...)
Affinity DataIC50: 1.00E+3nMT: 2°CAssay Description:Assays for ROCK inhibition were performed using the following protein constructs: glutathione S-transferase (GST)-tagged human ROCK1 catalytic domain...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2019
Entry Details
Go to US Patent

TargetRho-associated protein kinase 2(Human)
Lycera

US Patent
LigandPNGBDBM295751(US10112935, Example 34 | N-(4-(5-((4-Chloro-1H-ind...)
Affinity DataIC50: 1.00E+3nMT: 2°CAssay Description:Assays for ROCK inhibition were performed using the following protein constructs: glutathione S-transferase (GST)-tagged human ROCK1 catalytic domain...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2019
Entry Details
Go to US Patent