BDBM295056 3-(6-Amino-5-(3-methyl-1,2,4-oxadiazol-5-yl)pyridin-3-yl)-N-(2-hydroxy-2-methylpropyl)-4-methylbenzenesulfonamide, hydrochloride salt::US10112926, Example 10

SMILES Cc1noc(n1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)NCC(C)(C)O

InChI Key InChIKey=HAWIAVPLXUYCRU-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 295056   

LigandPNGBDBM295056(3-(6-Amino-5-(3-methyl-1,2,4-oxadiazol-5-yl)pyridi...)
Affinity DataIC50: 900nMpH: 7.5 T: 2°CAssay Description:The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM295056(3-(6-Amino-5-(3-methyl-1,2,4-oxadiazol-5-yl)pyridi...)
Affinity DataIC50: 4.30E+3nMpH: 7.5 T: 2°CAssay Description:The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM295056(3-(6-Amino-5-(3-methyl-1,2,4-oxadiazol-5-yl)pyridi...)
Affinity DataIC50: 9.80E+3nMpH: 7.5 T: 2°CAssay Description:The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetPhosphatidylinositol 4-kinase beta(Human)
Novartis

US Patent
LigandPNGBDBM295056(3-(6-Amino-5-(3-methyl-1,2,4-oxadiazol-5-yl)pyridi...)
Affinity DataIC50: 9.80E+3nMpH: 7.5 T: 2°CAssay Description:The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM295056(3-(6-Amino-5-(3-methyl-1,2,4-oxadiazol-5-yl)pyridi...)
Affinity DataIC50: 40nMpH: 7.5Assay Description:The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad, Calif., USA) (Cat. No. PV5099). The kit contains t...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM295056(3-(6-Amino-5-(3-methyl-1,2,4-oxadiazol-5-yl)pyridi...)
Affinity DataIC50: 550nMpH: 7.5Assay Description:The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad, Calif., USA) (Cat. No. PV5099). The kit contains t...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase mTOR(Human)
Novartis

US Patent
LigandPNGBDBM295056(3-(6-Amino-5-(3-methyl-1,2,4-oxadiazol-5-yl)pyridi...)
Affinity DataIC50: 4.20E+3nMpH: 7.5Assay Description:Binding Assays are based on the binding and displacement of an Alexa Fluor 647-labeled, ATP-competitive kinase inhibitors to the kinase of interest. ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM295056(3-(6-Amino-5-(3-methyl-1,2,4-oxadiazol-5-yl)pyridi...)
Affinity DataIC50: 40nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using phosphatidylinositol as substrate incubated for 30 to 60 mins in presence of ATP by TR-FRET based Adap...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM295056(3-(6-Amino-5-(3-methyl-1,2,4-oxadiazol-5-yl)pyridi...)
Affinity DataIC50: 900nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using L-alpha-phosphatidylinositol as substrate incubated for 30 to 60 mins in presence of ATP by Kinase Glo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM295056(3-(6-Amino-5-(3-methyl-1,2,4-oxadiazol-5-yl)pyridi...)
Affinity DataIC50: 200nMAssay Description:Inhibition of PI3Kgamma in human U937 cells assessed as reduction in AKT phosphorylation preincubated for 30 mins followed by MIP1alpha stimulation f...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed