BDBM295036 3-(6-amino-5-(2-methyl-2H-1,2,3-triazol-4-yl)pyridin-3-yl)-N-(2-hydroxy-2-methylpropyl)-4-methylbenzenesulfonamide hydrochloride::US10112926, Example 4.4

SMILES Cc1ccc(cc1-c1cnc(N)c(c1)-c1cnn(C)n1)S(=O)(=O)NCC(C)(C)O

InChI Key InChIKey=OUGWFIXWGKIEGR-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 295036   

LigandPNGBDBM295036(3-(6-amino-5-(2-methyl-2H-1,2,3-triazol-4-yl)pyrid...)
Affinity DataIC50: 560nMpH: 7.5 T: 2°CAssay Description:The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM295036(3-(6-amino-5-(2-methyl-2H-1,2,3-triazol-4-yl)pyrid...)
Affinity DataIC50: 2.95E+3nMpH: 7.5 T: 2°CAssay Description:The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM295036(3-(6-amino-5-(2-methyl-2H-1,2,3-triazol-4-yl)pyrid...)
Affinity DataIC50: 1.00E+4nMpH: 7.5 T: 2°CAssay Description:The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetPhosphatidylinositol 4-kinase beta(Human)
Novartis

US Patent
LigandPNGBDBM295036(3-(6-amino-5-(2-methyl-2H-1,2,3-triazol-4-yl)pyrid...)
Affinity DataIC50: 8.20E+3nMpH: 7.5 T: 2°CAssay Description:The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM295036(3-(6-amino-5-(2-methyl-2H-1,2,3-triazol-4-yl)pyrid...)
Affinity DataIC50: 212nMpH: 7.5Assay Description:The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad, Calif., USA) (Cat. No. PV5099). The kit contains t...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM295036(3-(6-amino-5-(2-methyl-2H-1,2,3-triazol-4-yl)pyrid...)
Affinity DataIC50: 1.85E+3nMpH: 7.5Assay Description:The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad, Calif., USA) (Cat. No. PV5099). The kit contains t...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase mTOR(Human)
Novartis

US Patent
LigandPNGBDBM295036(3-(6-amino-5-(2-methyl-2H-1,2,3-triazol-4-yl)pyrid...)
Affinity DataIC50: 1.00E+4nMpH: 7.5Assay Description:Binding Assays are based on the binding and displacement of an Alexa Fluor 647-labeled, ATP-competitive kinase inhibitors to the kinase of interest. ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM295036(3-(6-amino-5-(2-methyl-2H-1,2,3-triazol-4-yl)pyrid...)
Affinity DataIC50: 170nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using phosphatidylinositol as substrate incubated for 30 to 60 mins in presence of ATP by TR-FRET based Adap...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM295036(3-(6-amino-5-(2-methyl-2H-1,2,3-triazol-4-yl)pyrid...)
Affinity DataIC50: 570nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using L-alpha-phosphatidylinositol as substrate incubated for 30 to 60 mins in presence of ATP by Kinase Glo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM295036(3-(6-amino-5-(2-methyl-2H-1,2,3-triazol-4-yl)pyrid...)
Affinity DataIC50: 151nMAssay Description:Inhibition of PI3Kgamma in human U937 cells assessed as reduction in AKT phosphorylation preincubated for 30 mins followed by MIP1alpha stimulation f...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed