BDBM294510 US10111875, Compound 199

SMILES CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(cn1)C(=O)Nc1cccs1

InChI Key InChIKey=VSSLBLFWKAPMAH-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 294510   

TargetTyrosine-protein kinase JAK1(Human)
Hutchinson Medipharma

US Patent
LigandPNGBDBM294510(US10111875, Compound 199)
Affinity DataIC50: 14nMT: 2°CAssay Description:JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z&...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2019
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Hutchinson Medipharma

US Patent
LigandPNGBDBM294510(US10111875, Compound 199)
Affinity DataIC50: 75nMT: 2°CAssay Description:JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z&...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2019
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Hutchinson Medipharma

US Patent
LigandPNGBDBM294510(US10111875, Compound 199)
Affinity DataIC50: 522nMT: 2°CAssay Description:JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z&...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2019
Entry Details
Go to US Patent