BDBM292713 1-(5-Butoxy-2-chlorophenyl)-8-chloro-3-methyl-1H-pyrazolo[4,3-c][1,5]naphthyridin-4(5H)-one::US10105349, Example 20::US10543194, Example 20

SMILES CCCCOc1ccc(Cl)c(c1)-n1nc(C)c2c1c1nc(Cl)ccc1[nH]c2=O

InChI Key InChIKey=PCAMJUDIUZGFAB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 292713   

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Intra-Cellular Therapies

US Patent
LigandPNGBDBM292713(US10105349, Example 20 | 1-(5-Butoxy-2-chloropheny...)
Affinity DataIC50: 12nMpH: 7.2 T: 2°CAssay Description:Assay: PDE2A is assayed with FL-cAMP as substrate. An enzyme titration is first performed to determine the working concentration of PDE. The concentr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
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TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Intra-Cellular Therapies

US Patent
LigandPNGBDBM292713(US10105349, Example 20 | 1-(5-Butoxy-2-chloropheny...)
Affinity DataIC50: 12nMAssay Description:r-hPDE2A (Accession No. NM_002599, Homo sapiens phosphodiesterase 2A, cGMP-stimulated, transcript variant 1) A mammalian expression cloning vector wi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2020
Entry Details
Go to US Patent