BDBM291880 8-(1,3-dimethyl-1H-pyrazol-4-yl)-N-((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine::US11207325, Example 195::US9580437, Example 195

SMILES Cc1nn(C)cc1-c1cnc(NCc2c3CCOc3ccc2F)n2cnnc12

InChI Key InChIKey=HIOYDIJURIUQHD-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 291880   

LigandPNGBDBM291880(US9580437, Example 195 | 8-(1,3-dimethyl-1H-pyrazo...)
Affinity DataIC50: 5.90nMpH: 8.0Assay Description:To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM291880(US9580437, Example 195 | 8-(1,3-dimethyl-1H-pyrazo...)
Affinity DataIC50: 11.6nMpH: 8.0Assay Description:Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM291880(US9580437, Example 195 | 8-(1,3-dimethyl-1H-pyrazo...)
Affinity DataIC50: 2.40nMAssay Description:Cell lysates were transferred to the wells of a 384-well plate and the final volume was adjusted to 50 μL per well with PBS. The plate was seale...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetPolycomb protein EED(Human)
Novartis

US Patent
LigandPNGBDBM291880(US9580437, Example 195 | 8-(1,3-dimethyl-1H-pyrazo...)
Affinity DataIC50: 5.90nMAssay Description:To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetPolycomb protein EED(Human)
Novartis

US Patent
LigandPNGBDBM291880(US9580437, Example 195 | 8-(1,3-dimethyl-1H-pyrazo...)
Affinity DataIC50: 11.6nMAssay Description:Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetPolycomb protein EED(Human)
Novartis

US Patent
LigandPNGBDBM291880(US9580437, Example 195 | 8-(1,3-dimethyl-1H-pyrazo...)
Affinity DataIC50: 2.40nMAssay Description:Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra...More data for this Ligand-Target Pair
In DepthDetails
US Patent