BDBM291402 1-(2-((6-amino-5-(4-phenoxyphenyl)pyrimidin-4-yl)amino)-6-azaspiro[3.4]octan-6-yl)prop-2-en-1-one ::US10413562, Compound A113::US9580449, Example A113

SMILES Nc1ncnc(N[C@H]2CC3(C2)CCN(C3)C(=O)C=C)c1-c1ccc(Oc2ccccc2)cc1

InChI Key InChIKey=JFZCALKRMMKWKD-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 291402   

TargetTyrosine-protein kinase BTK(Human)
Merck Patent

US Patent
LigandPNGBDBM291402(1-(2-((6-amino-5-(4-phenoxyphenyl)pyrimidin-4-yl)a...)
Affinity DataIC50: 100nMpH: 7.5 T: 2°CAssay Description:The following describes a microfluidic, off-chip mobility shift kinase assay used to measure inherent potency of compounds against BTK enzyme. Compou...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Patent

US Patent
LigandPNGBDBM291402(1-(2-((6-amino-5-(4-phenoxyphenyl)pyrimidin-4-yl)a...)
Affinity DataIC50: 100nMAssay Description:2.5× stocks of full-length human BTK (08-080) from CarnaBio USA, Inc., Natick, Mass., 1.6×ATP and appropriate kinKDR peptide substrate (FITC-AHA-EEPL...More data for this Ligand-Target Pair
In DepthDetails
US Patent