BDBM291393 (E)-1-(6-((6-amino-5-(4-phenoxyphenyl)pyrimidin-4-yl)oxy)-2-azaspiro[3.3]heptan-2-yl)-4-(dimethylamino)but-2-en-1-one ::US10413562, Compound A105::US9580449, Example A105

SMILES CN(C)C\C=C\C(=O)N1CC2(CC(C2)Oc2ncnc(N)c2-c2ccc(Oc3ccccc3)cc2)C1

InChI Key InChIKey=GOHJQPIHXDUOJJ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 291393   

TargetTyrosine-protein kinase BTK(Human)
Merck Patent

US Patent
LigandPNGBDBM291393((E)-1-(6-((6-amino-5-(4-phenoxyphenyl)pyrimidin-4-...)
Affinity DataIC50: 100nMpH: 7.5 T: 2°CAssay Description:The following describes a microfluidic, off-chip mobility shift kinase assay used to measure inherent potency of compounds against BTK enzyme. Compou...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Patent

US Patent
LigandPNGBDBM291393((E)-1-(6-((6-amino-5-(4-phenoxyphenyl)pyrimidin-4-...)
Affinity DataIC50: 100nMAssay Description:2.5× stocks of full-length human BTK (08-080) from CarnaBio USA, Inc., Natick, Mass., 1.6×ATP and appropriate kinKDR peptide substrate (FITC-AHA-EEPL...More data for this Ligand-Target Pair
In DepthDetails
US Patent