BDBM291247 N-(5-(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-3'-oxo-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-[2,7]naphthyridine]-6'-yl)-1-(2-methoxyethyl)-1H-pyrazol-4-yl)acrylamide::US10016438, Example 15::US9580423, Example 15::US9801889, Example 15

SMILES COCCn1ncc(NC(=O)C=C)c1-c1cc2c(CN(C(=O)C22CC2)c2c(F)c(OC)cc(OC)c2F)cn1

InChI Key InChIKey=CMKMWXHORJDBGR-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 291247   

TargetFibroblast growth factor receptor 1(Human)
Incyte

US Patent
LigandPNGBDBM291247(N-(5-(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-3'-oxo...)
Affinity DataIC50: 200nMpH: 7.5Assay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2019
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 2(Human)
Incyte

US Patent
LigandPNGBDBM291247(N-(5-(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-3'-oxo...)
Affinity DataIC50: 200nMpH: 7.5Assay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2019
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 3(Human)
Incyte

US Patent
LigandPNGBDBM291247(N-(5-(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-3'-oxo...)
Affinity DataIC50: 200nMpH: 7.5Assay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2019
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 4(Human)
Incyte

US Patent
LigandPNGBDBM291247(N-(5-(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-3'-oxo...)
Affinity DataIC50: 10nMpH: 7.5Assay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2019
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 1(Human)
Incyte

US Patent
LigandPNGBDBM291247(N-(5-(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-3'-oxo...)
Affinity DataIC50: 200nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2019
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 2(Human)
Incyte

US Patent
LigandPNGBDBM291247(N-(5-(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-3'-oxo...)
Affinity DataIC50: 200nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2019
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 3(Human)
Incyte

US Patent
LigandPNGBDBM291247(N-(5-(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-3'-oxo...)
Affinity DataIC50: 200nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2019
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 4(Human)
Incyte

US Patent
LigandPNGBDBM291247(N-(5-(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-3'-oxo...)
Affinity DataIC50: 10nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2019
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 1(Human)
Incyte

US Patent
LigandPNGBDBM291247(N-(5-(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-3'-oxo...)
Affinity DataIC50: 200nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 2(Human)
Incyte

US Patent
LigandPNGBDBM291247(N-(5-(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-3'-oxo...)
Affinity DataIC50: 200nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 3(Human)
Incyte

US Patent
LigandPNGBDBM291247(N-(5-(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-3'-oxo...)
Affinity DataIC50: 200nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 4(Human)
Incyte

US Patent
LigandPNGBDBM291247(N-(5-(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-3'-oxo...)
Affinity DataIC50: 10nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details
Go to US Patent