BDBM291244 N-(5-(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-3'-oxo-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-[2,7]naphthyridine]-6'-yl)-2-(morpholinomethyl)phenyl)acrylamide::US10016438, Example 12::US9580423, Example 12::US9801889, Example 12

SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3C3(CC3)C2=O)-c2ccc(CN3CCOCC3)c(NC(=O)C=C)c2)c1F

InChI Key InChIKey=VCLIPTAHOIBJCI-UHFFFAOYSA-N

Data  24 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 24 hits for monomerid = 291244   

TargetFibroblast growth factor receptor 1(Human)
Incyte

US Patent
LigandPNGBDBM291244(N-(5-(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-3'-oxo...)
Affinity DataIC50: 200nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2019
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 4(Human)
Incyte

US Patent
LigandPNGBDBM291244(N-(5-(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-3'-oxo...)
Affinity DataIC50: 10nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 3(Human)
Incyte

US Patent
LigandPNGBDBM291244(N-(5-(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-3'-oxo...)
Affinity DataIC50: 115nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 2(Human)
Incyte

US Patent
LigandPNGBDBM291244(N-(5-(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-3'-oxo...)
Affinity DataIC50: 115nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 1(Human)
Incyte

US Patent
LigandPNGBDBM291244(N-(5-(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-3'-oxo...)
Affinity DataIC50: 200nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 4(Human)
Incyte

US Patent
LigandPNGBDBM291244(N-(5-(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-3'-oxo...)
Affinity DataIC50: 10nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 3(Human)
Incyte

US Patent
LigandPNGBDBM291244(N-(5-(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-3'-oxo...)
Affinity DataIC50: 20nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 2(Human)
Incyte

US Patent
LigandPNGBDBM291244(N-(5-(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-3'-oxo...)
Affinity DataIC50: 115nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 1(Human)
Incyte

US Patent
LigandPNGBDBM291244(N-(5-(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-3'-oxo...)
Affinity DataIC50: 200nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 4(Human)
Incyte

US Patent
LigandPNGBDBM291244(N-(5-(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-3'-oxo...)
Affinity DataIC50: 10nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2019
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 3(Human)
Incyte

US Patent
LigandPNGBDBM291244(N-(5-(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-3'-oxo...)
Affinity DataIC50: 115nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2019
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 2(Human)
Incyte

US Patent
LigandPNGBDBM291244(N-(5-(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-3'-oxo...)
Affinity DataIC50: 115nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2019
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 1(Human)
Incyte

US Patent
LigandPNGBDBM291244(N-(5-(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-3'-oxo...)
Affinity DataIC50: 200nMpH: 7.5Assay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2019
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 4(Human)
Incyte

US Patent
LigandPNGBDBM291244(N-(5-(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-3'-oxo...)
Affinity DataIC50: 10nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2019
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 3(Human)
Incyte

US Patent
LigandPNGBDBM291244(N-(5-(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-3'-oxo...)
Affinity DataIC50: 20nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2019
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 2(Human)
Incyte

US Patent
LigandPNGBDBM291244(N-(5-(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-3'-oxo...)
Affinity DataIC50: 115nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2019
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 1(Human)
Incyte

US Patent
LigandPNGBDBM291244(N-(5-(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-3'-oxo...)
Affinity DataIC50: 200nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2019
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 4(Human)
Incyte

US Patent
LigandPNGBDBM291244(N-(5-(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-3'-oxo...)
Affinity DataIC50: 10nMpH: 7.5Assay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2019
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 3(Human)
Incyte

US Patent
LigandPNGBDBM291244(N-(5-(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-3'-oxo...)
Affinity DataIC50: 115nMpH: 7.5Assay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2019
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 2(Human)
Incyte

US Patent
LigandPNGBDBM291244(N-(5-(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-3'-oxo...)
Affinity DataIC50: 115nMpH: 7.5Assay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2019
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 1(Human)
Incyte

US Patent
LigandPNGBDBM291244(N-(5-(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-3'-oxo...)
Affinity DataIC50: 200nMpH: 7.5Assay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2019
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 4(Human)
Incyte

US Patent
LigandPNGBDBM291244(N-(5-(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-3'-oxo...)
Affinity DataIC50: 10nMpH: 7.5Assay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2019
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 3(Human)
Incyte

US Patent
LigandPNGBDBM291244(N-(5-(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-3'-oxo...)
Affinity DataIC50: 20nMpH: 7.5Assay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2019
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 2(Human)
Incyte

US Patent
LigandPNGBDBM291244(N-(5-(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-3'-oxo...)
Affinity DataIC50: 115nMpH: 7.5Assay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2019
Entry Details
Go to US Patent