BDBM291172 2-hydroxy-N,N-dimethyl-3-(2-{[(5-methylfuran-2-yl)-(2-methyltetrahydrofuran-2-yl)methyl]amino}-3,4-dioxocyclobut-1-enylamino)benzamide::US9580412, Example 1

SMILES CNC(=O)c1cccc(NC2C(NC(c3ccc(C)o3)C3(C)CCCO3)C(=O)C2=O)c1O

InChI Key InChIKey=AGJIIPQAPDGVQW-UHFFFAOYSA-N

Data  13 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 291172   

TargetC-X-C chemokine receptor type 1(Human)
Galderma Research & Development

US Patent
LigandPNGBDBM291172(2-hydroxy-N,N-dimethyl-3-(2-{[(5-methylfuran-2-yl)...)
Affinity DataIC50: 244nMAssay Description:The in vitro affinity of the compounds of the present invention for the CXCR1 and CXCR2 receptors was determined on a functional test of the β-a...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetC-X-C chemokine receptor type 2(Human)
Galderma Research & Development

US Patent
LigandPNGBDBM291172(2-hydroxy-N,N-dimethyl-3-(2-{[(5-methylfuran-2-yl)...)
Affinity DataIC50: 53nMAssay Description:The in vitro affinity of the compounds of the present invention for the CXCR1 and CXCR2 receptors was determined on a functional test of the β-a...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetC-X-C chemokine receptor type 1(Human)
Galderma Research & Development

US Patent
LigandPNGBDBM291172(2-hydroxy-N,N-dimethyl-3-(2-{[(5-methylfuran-2-yl)...)
Affinity DataIC50: 1.00E+4nMAssay Description:The in vitro affinity of the compounds of the present invention for the CXCR1 and CXCR2 receptors was determined on a functional test of the β-a...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetC-X-C chemokine receptor type 2(Human)
Galderma Research & Development

US Patent
LigandPNGBDBM291172(2-hydroxy-N,N-dimethyl-3-(2-{[(5-methylfuran-2-yl)...)
Affinity DataIC50: 1.00E+4nMAssay Description:The in vitro affinity of the compounds of the present invention for the CXCR1 and CXCR2 receptors was determined on a functional test of the β-a...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetC-X-C chemokine receptor type 1(Human)
Galderma Research & Development

US Patent
LigandPNGBDBM291172(2-hydroxy-N,N-dimethyl-3-(2-{[(5-methylfuran-2-yl)...)
Affinity DataIC50: 1.00E+4nMAssay Description:The in vitro affinity of the compounds of the present invention for the CXCR1 and CXCR2 receptors was determined on a functional test of the β-a...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetC-X-C chemokine receptor type 2(Human)
Galderma Research & Development

US Patent
LigandPNGBDBM291172(2-hydroxy-N,N-dimethyl-3-(2-{[(5-methylfuran-2-yl)...)
Affinity DataIC50: 1.00E+4nMAssay Description:The in vitro affinity of the compounds of the present invention for the CXCR1 and CXCR2 receptors was determined on a functional test of the β-a...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetC-X-C chemokine receptor type 1(Human)
Galderma Research & Development

US Patent
LigandPNGBDBM291172(2-hydroxy-N,N-dimethyl-3-(2-{[(5-methylfuran-2-yl)...)
Affinity DataIC50: 1.00E+4nMAssay Description:The in vitro affinity of the compounds of the present invention for the CXCR1 and CXCR2 receptors was determined on a functional test of the β-a...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetC-X-C chemokine receptor type 2(Human)
Galderma Research & Development

US Patent
LigandPNGBDBM291172(2-hydroxy-N,N-dimethyl-3-(2-{[(5-methylfuran-2-yl)...)
Affinity DataIC50: 1.00E+4nMAssay Description:The in vitro affinity of the compounds of the present invention for the CXCR1 and CXCR2 receptors was determined on a functional test of the β-a...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetC-C chemokine receptor type 4(Human)
Galderma Research & Development

US Patent
LigandPNGBDBM291172(2-hydroxy-N,N-dimethyl-3-(2-{[(5-methylfuran-2-yl)...)
Affinity DataIC50: 410nMAssay Description:The in vitro affinity of the compounds of the present invention for the CXCR1 and CXCR2 receptors was determined on a functional test of the β-a...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetC-C chemokine receptor type 6(Human)
Galderma Research & Development

US Patent
LigandPNGBDBM291172(2-hydroxy-N,N-dimethyl-3-(2-{[(5-methylfuran-2-yl)...)
Affinity DataIC50: 2nMAssay Description:The in vitro affinity of the compounds of the present invention for the CXCR1 and CXCR2 receptors was determined on a functional test of the β-a...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetC-X-C chemokine receptor type 3(Human)
Galderma Research & Development

US Patent
LigandPNGBDBM291172(2-hydroxy-N,N-dimethyl-3-(2-{[(5-methylfuran-2-yl)...)
Affinity DataIC50: 1.30nMAssay Description:The in vitro affinity of the compounds of the present invention for the CXCR1 and CXCR2 receptors was determined on a functional test of the β-a...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetC-C chemokine receptor type 6(Human)
Galderma Research & Development

US Patent
LigandPNGBDBM291172(2-hydroxy-N,N-dimethyl-3-(2-{[(5-methylfuran-2-yl)...)
Affinity DataIC50: 2.20nMAssay Description:The in vitro affinity of the compounds of the present invention for the CXCR1 and CXCR2 receptors was determined on a functional test of the β-a...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetC-X-C chemokine receptor type 3(Human)
Galderma Research & Development

US Patent
LigandPNGBDBM291172(2-hydroxy-N,N-dimethyl-3-(2-{[(5-methylfuran-2-yl)...)
Affinity DataIC50: 55nMAssay Description:The in vitro affinity of the compounds of the present invention for the CXCR1 and CXCR2 receptors was determined on a functional test of the β-a...More data for this Ligand-Target Pair
In DepthDetails
US Patent