BDBM289984 2-Methyl-8-{6-[5-(2H-pyrazol-3- yl)-pyridin-2-yloxy]-benzofuran-3- ylmethyl}-2,8-diaza-spiro[4.5]decan- 1-one::US9573957, Example 110

SMILES CN1CCC2(CCN(Cc3coc4cc(Oc5ccc(cn5)-c5ccn[nH]5)ccc34)CC2)C1=O

InChI Key InChIKey=SQCWUMLVNXRIJD-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 289984   

TargetLeukotriene A-4 hydrolase(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM289984(2-Methyl-8-{6-[5-(2H-pyrazol-3- yl)-pyridin-2-ylox...)
Affinity DataIC50: 0.220nMpH: 7.5 T: 2°CAssay Description:The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...More data for this Ligand-Target Pair
In DepthDetails
US Patent