BDBM289579 8-(8-Oxa-3-azabicyclo[3.2.1]octan-3-ylmethyl)-6-(4-methoxybenzyl)-9-methylthieno[3,2-e][1,2,4]triazolo[1,5-c]pyrimidin-5(6H)-one::US10092575, Example 67::US10376514, Example 67

SMILES COc1ccc(Cn2c3sc(CN4CC5CCC(C4)O5)c(C)c3c3ncnn3c2=O)cc1

InChI Key InChIKey=BSAVECNSARKZIM-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 289579   

LigandPNGBDBM289579(8-(8-Oxa-3-azabicyclo[3.2.1]octan-3-ylmethyl)-6-(4...)
Affinity DataEC50: <100nMT: 2°CAssay Description:The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...More data for this Ligand-Target Pair
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LigandPNGBDBM289579(8-(8-Oxa-3-azabicyclo[3.2.1]octan-3-ylmethyl)-6-(4...)
Affinity DataIC50: 100nMT: 2°CAssay Description:PDE1B inhibition was determined by an IMAP TR-FRET assay. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or c...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM289579(8-(8-Oxa-3-azabicyclo[3.2.1]octan-3-ylmethyl)-6-(4...)
Affinity DataIC50: 100nMAssay Description:The selectivity of compounds of the present invention was determined using a panel of recombinant human PDEs and an in vitro enzymatic assay (BPS Bio...More data for this Ligand-Target Pair
In DepthDetails
US Patent