BDBM289546 8-((4-Ethyl-3-oxopiperazin-1-yl)methyl)-6-(4-methoxybenzyl)thieno[3,2-e][1,2,4]triazolo[1,5-c]pyrimidin-5(6H)-one::US10092575, Example 34::US10376514, Example 34

SMILES CCN1CCN(Cc2cc3c4ncnn4c(=O)n(Cc4ccc(OC)cc4)c3s2)CC1=O

InChI Key InChIKey=XPLOSUPPLOGKJB-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 289546   

LigandPNGBDBM289546(8-((4-Ethyl-3-oxopiperazin-1-yl)methyl)-6-(4-metho...)
Affinity DataEC50: <100nMT: 2°CAssay Description:The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...More data for this Ligand-Target Pair
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LigandPNGBDBM289546(8-((4-Ethyl-3-oxopiperazin-1-yl)methyl)-6-(4-metho...)
Affinity DataIC50: 100nMT: 2°CAssay Description:PDE1B inhibition was determined by an IMAP TR-FRET assay. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or c...More data for this Ligand-Target Pair
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US Patent

LigandPNGBDBM289546(8-((4-Ethyl-3-oxopiperazin-1-yl)methyl)-6-(4-metho...)
Affinity DataIC50: 100nMAssay Description:The selectivity of compounds of the present invention was determined using a panel of recombinant human PDEs and an in vitro enzymatic assay (BPS Bio...More data for this Ligand-Target Pair
In DepthDetails
US Patent