BDBM289481 1-(4-(6-amino-5-(tri- fluoromethoxy)pyridin- 3-yl)-1-(bicyclo[1.1.1]- pentan-1-yl)-1H-imid- azol-2-yl)-2-methyl- propan-1-ol::US10093664, Example 57::US10093664, Example 62

SMILES CC(C)C(O)c1nc(cn1C12CC(C1)C2)-c1cnc(N)c(OC(F)(F)F)c1

InChI Key InChIKey=BSZDQUPRFFLOJT-UHFFFAOYSA-N

Data  1 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 289481   

TargetMitogen-activated protein kinase kinase kinase 12(Human)
The University of Texas System

US Patent
LigandPNGBDBM289481(US10093664, Example 57 | US10093664, Example 62 | ...)
Affinity DataKd:  0.620nMAssay Description:The DLK dissociation constants (Kd) have been determined in the KINOMEscan KdELECT Service at DiscoveRx. A fusion protein of full length of human DLK...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/22/2019
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase kinase kinase 12(Human)
The University of Texas System

US Patent
LigandPNGBDBM289481(US10093664, Example 57 | US10093664, Example 62 | ...)
Affinity DataKd:  1.10nMAssay Description:The DLK dissociation constants (Kd) have been determined in the KINOMEscan KdELECT Service at DiscoveRx. A fusion protein of full length of human DLK...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/22/2019
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase kinase kinase 12(Human)
The University of Texas System

US Patent
LigandPNGBDBM289481(US10093664, Example 57 | US10093664, Example 62 | ...)
Affinity DataIC50: 39nMAssay Description:Inhibition of doxycycline-inducible human DLK transfected in HEK293 cells assessed as reduction in c-Jun phosphorylation at Ser63 residue incubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed