BDBM287619 N-(2-(4-(dimethylamino)piperidin-1-yl)-4-methoxy-5-(7-methylpyrrolo[1,2-f][1,2,4]triazin-2-yl amino)phenyl)acrylamide::US10085983, Compound J-14

SMILES COc1cc(N2CCC(CC2)N(C)C)c(NC(=O)C=C)cc1Nc1ncc2ccc(C)n2n1

InChI Key InChIKey=UNAKDSAXWVXYRR-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 287619   

TargetEpidermal growth factor receptor [668-1210,T790M,L858R](Human)
Shanghai Haiyan Pharmaceutical Technology

US Patent
LigandPNGBDBM287619(US10085983, Compound J-14 | N-(2-(4-(dimethylamino...)
Affinity DataIC50: 9nMT: 2°CAssay Description:All reagents used in the following z′-lyte assay were purchased from Invitrogen.The inhibitory activity on T790M/L858R double mutant EGFR kinas...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetEpidermal growth factor receptor(Human)
Shanghai Haiyan Pharmaceutical Technology

US Patent
LigandPNGBDBM287619(US10085983, Compound J-14 | N-(2-(4-(dimethylamino...)
Affinity DataIC50: 104nMT: 2°CAssay Description:All reagents used in the following z′-lyte assay were purchased from Invitrogen.The inhibitory activity on T790M/L858R double mutant EGFR kinas...More data for this Ligand-Target Pair
In DepthDetails
US Patent