BDBM286329 4-([1,2,4]triazolo[1,5- a]pyridin-2- yl)isoquinoline::US9567333, 5

SMILES c1ccn2nc(nc2c1)-c1cncc2ccccc12

InChI Key InChIKey=ZJIAPQYOKFFZAQ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 286329   

TargetCytochrome P450 11B2, mitochondrial(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM286329(4-([1,2,4]triazolo[1,5- a]pyridin-2- yl)isoquinoli...)
Affinity DataIC50: 138nMAssay Description:CYP11B1 Assays: V79 cell lines stably expressing the either the human CYP11B2 or the human CYP11B1 enzyme were generated using a standard transfectio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/14/2019
Entry Details
Go to US Patent

TargetCytochrome P450 11B1, mitochondrial(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM286329(4-([1,2,4]triazolo[1,5- a]pyridin-2- yl)isoquinoli...)
Affinity DataIC50: 8.33E+3nMAssay Description:CYP11B1 Assays: V79 cell lines stably expressing the either the human CYP11B2 or the human CYP11B1 enzyme were generated using a standard transfectio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/14/2019
Entry Details
Go to US Patent