BDBM286052 N-(2-(3-Chlorophenyl)-1-ethyl-1H-pyrrolo[3,2-b]pyridin-5-yl)-2-(difluoromethyl)-5-(((2-fluoro-2-methyl-propanoyl)amino)methyl)nicotinamide::US10081629, Example 37

SMILES CCn1c(cc2nc(NC(=O)c3cc(CNC(=O)C(C)(C)F)cnc3C(F)F)ccc12)-c1cccc(Cl)c1

InChI Key InChIKey=DXPCSEBCKXUVMV-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 286052   

TargetProstaglandin E synthase(Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM286052(US10081629, Example 37 | N-(2-(3-Chlorophenyl)-1-e...)
Affinity DataIC50: 6.46nMAssay Description:mPGES1 was diluted with assay buffer and added into plate at 49 μL/well supplemented with 1 μL of compound (the final concentration of each...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2019
Entry Details
Go to US Patent

TargetProstaglandin E synthase(Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM286052(US10081629, Example 37 | N-(2-(3-Chlorophenyl)-1-e...)
Affinity DataIC50: 22.4nMAssay Description:mPGES1 was diluted with assay buffer and added into plate at 49 μL/well supplemented with 1 μL of compound (the final concentration of each...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2019
Entry Details
Go to US Patent

TargetProstaglandin E synthase(Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM286052(US10081629, Example 37 | N-(2-(3-Chlorophenyl)-1-e...)
Affinity DataIC50: 22.4nMAssay Description:mPGES1 was diluted with assay buffer and added into plate at 49 μL/well supplemented with 1 μL of compound (the final concentration of each...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2019
Entry Details
Go to US Patent