BDBM286051 N-(2-(3-Chlorophenyl)-1-methyl-1H-pyrrolo[2,3-c]pyridin-5-yl)-2-(difluoromethyl)-5-(((2-fluoro-2-methyl-propanoyl)amino)methyl)nicotinamide::US10081629, Example 36

SMILES Cn1c(cc2cc(NC(=O)c3cc(CNC(=O)C(C)(C)F)cnc3C(F)F)ncc12)-c1cccc(Cl)c1

InChI Key InChIKey=HCGRNGVKLHUAJI-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 286051   

TargetProstaglandin E synthase(Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM286051(US10081629, Example 36 | N-(2-(3-Chlorophenyl)-1-m...)
Affinity DataIC50: 4.19nMAssay Description:mPGES1 was diluted with assay buffer and added into plate at 49 μL/well supplemented with 1 μL of compound (the final concentration of each...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetProstaglandin E synthase(Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM286051(US10081629, Example 36 | N-(2-(3-Chlorophenyl)-1-m...)
Affinity DataIC50: 13.2nMAssay Description:mPGES1 was diluted with assay buffer and added into plate at 49 μL/well supplemented with 1 μL of compound (the final concentration of each...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetProstaglandin E synthase(Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM286051(US10081629, Example 36 | N-(2-(3-Chlorophenyl)-1-m...)
Affinity DataIC50: 13.2nMAssay Description:mPGES1 was diluted with assay buffer and added into plate at 49 μL/well supplemented with 1 μL of compound (the final concentration of each...More data for this Ligand-Target Pair
In DepthDetails
US Patent