BDBM28546 N,5,12-trimethyl-4-phenyl-3,5,7,10,12-pentaazatricyclo[7.3.0.0^{2,6}]dodeca-1,3,6,8,10-pentaen-8-amine::imidazole-based tricyclic inhibitor, 17

SMILES CNc1nc2n(C)c(nc2c2n(C)cnc12)-c1ccccc1

InChI Key InChIKey=FUTLJNOGKQFKCL-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 28546   

LigandPNGBDBM28546(N,5,12-trimethyl-4-phenyl-3,5,7,10,12-pentaazatric...)
Affinity DataIC50: 520nMpH: 7.5 T: 2°CAssay Description:Assays measuring the enzyme catalyzed phosphorylation of GST-I-kappa-B-alpha were performed by adding enzyme at room temperature to substrate solutio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2009
Entry Details Article
PubMed
LigandPNGBDBM28546(N,5,12-trimethyl-4-phenyl-3,5,7,10,12-pentaazatric...)
Affinity DataIC50: 4.30E+3nMT: 2°CAssay Description:Assays measuring the enzyme catalyzed phosphorylation of GST-I-kappa-B-alpha were performed by adding enzyme at room temperature to substrate solutio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2009
Entry Details Article
PubMed
LigandPNGBDBM28546(N,5,12-trimethyl-4-phenyl-3,5,7,10,12-pentaazatric...)
Affinity DataIC50: 4.28E+3nMAssay Description:Inhibition of IKK1-catalyzed phosphorylation of GST-tagged IkappaBalpha fusion protein by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
LigandPNGBDBM28546(N,5,12-trimethyl-4-phenyl-3,5,7,10,12-pentaazatric...)
Affinity DataIC50: 520nMAssay Description:Inhibition of IKK2-catalyzed phosphorylation of GST-tagged IkappaBalpha fusion protein by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed