BDBM284755 US10023575, Example 46::US10023575, Example 47::US10023575, Example 81a::US10023575, Example 81b::US10479794, Example 81b::US10875867, Example 47::US11691977, Example 47

SMILES Cc1cnc2c(cnn2c1)C(=O)NC1(CCOCC1O)c1ccc(cc1F)C(F)(F)F

InChI Key InChIKey=ZRHWIJMFMCTNSD-UHFFFAOYSA-N

Data  24 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 24 hits for monomerid = 284755   

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Boehringer Ingelheim International

US Patent

LigandBDBM284755(US10023575, Example 46 | US10023575, Example 47 | ...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:The inhibition of PDE 2A or 10 enzyme activity was assessed using IMAP-Phosphodiesterase-cAMP fluorescence labeled substrate (Molecular Devices, Orde...More data for this Ligand-Target Pair

Target InfoPDBKEGG
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Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
9/25/2020
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TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Boehringer Ingelheim International

US Patent

LigandBDBM284755(US10023575, Example 46 | US10023575, Example 47 | ...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Assay Principle: The PDE reaction cleaves cAMP to AMP. The IMAP system (Molecular Device) using fluorescence polarization (FP) as detection principle...More data for this Ligand-Target Pair

Target InfoPDBKEGG
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Ligand InfoPC cidPC sidSimilars

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Date in BDB:
8/6/2023
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TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Boehringer Ingelheim International

US Patent

LigandBDBM284755(US10023575, Example 46 | US10023575, Example 47 | ...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Assay Principle: The PDE reaction cleaves cAMP to AMP. The IMAP system (Molecular Device) using fluorescence polarization (FP) as detection principle...More data for this Ligand-Target Pair

Target InfoPDBKEGG
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Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/6/2023
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TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Boehringer Ingelheim International

US Patent

LigandBDBM284755(US10023575, Example 46 | US10023575, Example 47 | ...)Copy SMILESCopy InChI

Affinity DataIC50: 240nMAssay Description:Assay Principle: The PDE reaction cleaves cAMP to AMP. The IMAP system (Molecular Device) using fluorescence polarization (FP) as detection principle...More data for this Ligand-Target Pair

Target InfoPDB
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Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/6/2023
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TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Boehringer Ingelheim International

US Patent

LigandBDBM284755(US10023575, Example 46 | US10023575, Example 47 | ...)Copy SMILESCopy InChI

Affinity DataIC50: 5.70nMAssay Description:Assay Principle: The PDE reaction cleaves cAMP to AMP. The IMAP system (Molecular Device) using fluorescence polarization (FP) as detection principle...More data for this Ligand-Target Pair

Target InfoPDB
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Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/6/2023
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TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Boehringer Ingelheim International

US Patent

LigandBDBM284755(US10023575, Example 46 | US10023575, Example 47 | ...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:The inhibition of PDE 2A or 10 enzyme activity was assessed using IMAP-Phosphodiesterase-cAMP fluorescence labeled substrate (Molecular Devices, Orde...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
7/25/2021
Entry Details
Copy Entry DOIGo to US Patent

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TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Boehringer Ingelheim International

US Patent

LigandBDBM284755(US10023575, Example 46 | US10023575, Example 47 | ...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:The inhibition of PDE 2A or 10 enzyme activity was assessed using IMAP-Phosphodiesterase-cAMP fluorescence labeled substrate (Molecular Devices, Orde...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
7/25/2021
Entry Details
Copy Entry DOIGo to US Patent

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TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Boehringer Ingelheim International

US Patent

LigandBDBM284755(US10023575, Example 46 | US10023575, Example 47 | ...)Copy SMILESCopy InChI

Affinity DataIC50: 240nMAssay Description:The inhibition of PDE 2A or 10 enzyme activity was assessed using IMAP-Phosphodiesterase-cAMP fluorescence labeled substrate (Molecular Devices, Orde...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
7/25/2021
Entry Details
Copy Entry DOIGo to US Patent

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TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Boehringer Ingelheim International

US Patent

LigandBDBM284755(US10023575, Example 46 | US10023575, Example 47 | ...)Copy SMILESCopy InChI

Affinity DataIC50: 5.70nMAssay Description:The inhibition of PDE 2A or 10 enzyme activity was assessed using IMAP-Phosphodiesterase-cAMP fluorescence labeled substrate (Molecular Devices, Orde...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
7/25/2021
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Boehringer Ingelheim International

US Patent

LigandBDBM284755(US10023575, Example 46 | US10023575, Example 47 | ...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:The inhibition of PDE 2A or 10 enzyme activity was assessed using IMAP-Phosphodiesterase-cAMP fluorescence labeled substrate (Molecular Devices, Orde...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
9/25/2020
Entry Details
Copy Entry DOIGo to US Patent

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TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Boehringer Ingelheim International

US Patent

LigandBDBM284755(US10023575, Example 46 | US10023575, Example 47 | ...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:The inhibition of PDE 2A or 10 enzyme activity was assessed using IMAP-Phosphodiesterase-cAMP fluorescence labeled substrate (Molecular Devices, Orde...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
9/25/2020
Entry Details
Copy Entry DOIGo to US Patent

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TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Boehringer Ingelheim International

US Patent

LigandBDBM284755(US10023575, Example 46 | US10023575, Example 47 | ...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:The inhibition of PDE 2A or 10 enzyme activity was assessed using IMAP-Phosphodiesterase-cAMP fluorescence labeled substrate (Molecular Devices, Orde...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
9/25/2020
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Boehringer Ingelheim International

US Patent

LigandBDBM284755(US10023575, Example 46 | US10023575, Example 47 | ...)Copy SMILESCopy InChI

Affinity DataIC50: 5.70nMT: 2°CAssay Description:All reactions were performed in 384 well plates, Perkin Elmer black optiplates and IMAP reaction buffer with 0.1% Tween20 (kit component)Compounds we...More data for this Ligand-Target Pair

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Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
1/10/2019
Entry Details
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TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Boehringer Ingelheim International

US Patent

LigandBDBM284755(US10023575, Example 46 | US10023575, Example 47 | ...)Copy SMILESCopy InChI

Affinity DataIC50: 149nMAssay Description:The inhibition of PDE 2A or 10 enzyme activity was assessed using IMAP-Phosphodiesterase-cAMP fluorescence labeled substrate (Molecular Devices, Orde...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
9/25/2020
Entry Details
Copy Entry DOIGo to US Patent

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TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Boehringer Ingelheim International

US Patent

LigandBDBM284755(US10023575, Example 46 | US10023575, Example 47 | ...)Copy SMILESCopy InChI

Affinity DataIC50: 3.40nMAssay Description:The inhibition of PDE 2A or 10 enzyme activity was assessed using IMAP-Phosphodiesterase-cAMP fluorescence labeled substrate (Molecular Devices, Orde...More data for this Ligand-Target Pair

Target InfoPDB
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Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
9/25/2020
Entry Details
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TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Boehringer Ingelheim International

US Patent

LigandBDBM284755(US10023575, Example 46 | US10023575, Example 47 | ...)Copy SMILESCopy InChI

Affinity DataIC50: 240nMAssay Description:The inhibition of PDE 2A or 10 enzyme activity was assessed using IMAP-Phosphodiesterase-cAMP fluorescence labeled substrate (Molecular Devices, Orde...More data for this Ligand-Target Pair

Target InfoPDB
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Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
9/25/2020
Entry Details
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TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Boehringer Ingelheim International

US Patent

LigandBDBM284755(US10023575, Example 46 | US10023575, Example 47 | ...)Copy SMILESCopy InChI

Affinity DataIC50: 5.70nMAssay Description:The inhibition of PDE 2A or 10 enzyme activity was assessed using IMAP-Phosphodiesterase-cAMP fluorescence labeled substrate (Molecular Devices, Orde...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
9/25/2020
Entry Details
Copy Entry DOIGo to US Patent

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TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Boehringer Ingelheim International

US Patent

LigandBDBM284755(US10023575, Example 46 | US10023575, Example 47 | ...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMT: 2°CAssay Description:All reactions were performed in 384 well plates, Perkin Elmer black optiplates and IMAP reaction buffer with 0.1% Tween20 (kit component)Compounds we...More data for this Ligand-Target Pair

Target InfoPDBKEGG
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Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
1/10/2019
Entry Details
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TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Boehringer Ingelheim International

US Patent

LigandBDBM284755(US10023575, Example 46 | US10023575, Example 47 | ...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMT: 2°CAssay Description:All reactions were performed in 384 well plates, Perkin Elmer black optiplates and IMAP reaction buffer with 0.1% Tween20 (kit component)Compounds we...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
1/10/2019
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Boehringer Ingelheim International

US Patent

LigandBDBM284755(US10023575, Example 46 | US10023575, Example 47 | ...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMT: 2°CAssay Description:All reactions were performed in 384 well plates, Perkin Elmer black optiplates and IMAP reaction buffer with 0.1% Tween20 (kit component)Compounds we...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
1/10/2019
Entry Details
Copy Entry DOIGo to US Patent

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TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Boehringer Ingelheim International

US Patent

LigandBDBM284755(US10023575, Example 46 | US10023575, Example 47 | ...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMT: 2°CAssay Description:All reactions were performed in 384 well plates, Perkin Elmer black optiplates and IMAP reaction buffer with 0.1% Tween20 (kit component)Compounds we...More data for this Ligand-Target Pair

Target InfoPDBKEGG
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Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
1/10/2019
Entry Details
Copy Entry DOIGo to US Patent

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TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Boehringer Ingelheim International

US Patent

LigandBDBM284755(US10023575, Example 46 | US10023575, Example 47 | ...)Copy SMILESCopy InChI

Affinity DataIC50: 149nMT: 2°CAssay Description:All reactions were performed in 384 well plates, Perkin Elmer black optiplates and IMAP reaction buffer with 0.1% Tween20 (kit component)Compounds we...More data for this Ligand-Target Pair

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Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
1/10/2019
Entry Details
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TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Boehringer Ingelheim International

US Patent

LigandBDBM284755(US10023575, Example 46 | US10023575, Example 47 | ...)Copy SMILESCopy InChI

Affinity DataIC50: 3.40nMT: 2°CAssay Description:All reactions were performed in 384 well plates, Perkin Elmer black optiplates and IMAP reaction buffer with 0.1% Tween20 (kit component)Compounds we...More data for this Ligand-Target Pair

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In Depth
Date in BDB:
1/10/2019
Entry Details
Copy Entry DOIGo to US Patent

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TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Boehringer Ingelheim International

US Patent

LigandBDBM284755(US10023575, Example 46 | US10023575, Example 47 | ...)Copy SMILESCopy InChI

Affinity DataIC50: 240nMT: 2°CAssay Description:All reactions were performed in 384 well plates, Perkin Elmer black optiplates and IMAP reaction buffer with 0.1% Tween20 (kit component)Compounds we...More data for this Ligand-Target Pair

Target InfoPDB
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Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
1/10/2019
Entry Details
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