BDBM284705 US10023570, Example 740::US10174027, Example 740

SMILES COc1ccc(CN2CCN(CC2)c2ccc(cc2)-c2cc(cn3ncc(C#N)c23)-c2cnn(C)c2)cn1

InChI Key InChIKey=XTLUQTUNMHEHOP-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 284705   

LigandPNGBDBM284705(US10023570, Example 740 | US10174027, Example 740)
Affinity DataIC50: 4nMpH: 7.4Assay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK a...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM284705(US10023570, Example 740 | US10174027, Example 740)
Affinity DataIC50: 38.6nMpH: 7.4Assay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK a...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandPNGBDBM284705(US10023570, Example 740 | US10174027, Example 740)
Affinity DataIC50: 4nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK a...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM284705(US10023570, Example 740 | US10174027, Example 740)
Affinity DataIC50: 38.6nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK a...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandPNGBDBM284705(US10023570, Example 740 | US10174027, Example 740)
Affinity DataIC50: 4nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE-TK as...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM284705(US10023570, Example 740 | US10174027, Example 740)
Affinity DataIC50: 38.6nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE-TK as...More data for this Ligand-Target Pair
In DepthDetails
US Patent