BDBM284119 N-benzyl-4-(5-(3-cyano-6- (1-methyl-1H-pyrazol-4- yl)pyrazolo[1,5-a]pyridin-4- yl)pyridin-2-yl)piperazine- 1-carboxamide::US10023570, Example 129::US10174027, Example 129

SMILES Cn1cc(cn1)-c1cc(-c2ccc(nc2)N2CCN(CC2)C(=O)NCc2ccccc2)c2c(cnn2c1)C#N

InChI Key InChIKey=CNKUBBQWEPDXNX-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 284119   

LigandPNGBDBM284119(US10023570, Example 129 | N-benzyl-4-(5-(3-cyano-6...)
Affinity DataIC50: 2.90nMpH: 7.4Assay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK a...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM284119(US10023570, Example 129 | N-benzyl-4-(5-(3-cyano-6...)
Affinity DataIC50: 17.3nMpH: 7.4Assay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK a...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandPNGBDBM284119(US10023570, Example 129 | N-benzyl-4-(5-(3-cyano-6...)
Affinity DataIC50: 2.90nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE-TK as...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM284119(US10023570, Example 129 | N-benzyl-4-(5-(3-cyano-6...)
Affinity DataIC50: 17.3nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE-TK as...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandPNGBDBM284119(US10023570, Example 129 | N-benzyl-4-(5-(3-cyano-6...)
Affinity DataIC50: 2.90nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK a...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM284119(US10023570, Example 129 | N-benzyl-4-(5-(3-cyano-6...)
Affinity DataIC50: 17.3nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK a...More data for this Ligand-Target Pair
In DepthDetails
US Patent