BDBM284043 US10023570, Example 53::US10174027, Example 53

SMILES CC(C)C[C@@H](O)C(=O)N1CCN(CC1)c1ccc(cn1)-c1cc(cn2ncc(C#N)c12)-c1cnn(C)c1

InChI Key InChIKey=WWVBTLJWZXISQA-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 284043   

LigandPNGBDBM284043(US10023570, Example 53 | US10174027, Example 53)
Affinity DataIC50: 4.40nMpH: 7.4Assay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK a...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM284043(US10023570, Example 53 | US10174027, Example 53)
Affinity DataIC50: 74.6nMpH: 7.4Assay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK a...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandPNGBDBM284043(US10023570, Example 53 | US10174027, Example 53)
Affinity DataIC50: 4.40nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE-TK as...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM284043(US10023570, Example 53 | US10174027, Example 53)
Affinity DataIC50: 74.6nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE-TK as...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandPNGBDBM284043(US10023570, Example 53 | US10174027, Example 53)
Affinity DataIC50: 4.40nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK a...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM284043(US10023570, Example 53 | US10174027, Example 53)
Affinity DataIC50: 74.6nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK a...More data for this Ligand-Target Pair
In DepthDetails
US Patent