BDBM284041 4-(6-(4-(2,6- difluorobenzoyl)piperazin- 1-yl)pyridin-3-yl)-6-(1- methyl-1H-pyrazol-4- yl)pyrazolo[1,5-a]pyridine- 3-carbonitrile 2,2,2- trifluoroacetate::US10023570, Example 51::US10174027, Example 51

SMILES Cn1cc(cn1)-c1cc(-c2ccc(nc2)N2CCN(CC2)C(=O)c2c(F)cccc2F)c2c(cnn2c1)C#N

InChI Key InChIKey=HMCBOGXXEQXQEV-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 284041   

LigandPNGBDBM284041(US10023570, Example 51 | 4-(6-(4-(2,6- difluoroben...)
Affinity DataIC50: 4.10nMpH: 7.4Assay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK a...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandPNGBDBM284041(US10023570, Example 51 | 4-(6-(4-(2,6- difluoroben...)
Affinity DataIC50: 4.10nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE-TK as...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandPNGBDBM284041(US10023570, Example 51 | 4-(6-(4-(2,6- difluoroben...)
Affinity DataIC50: 4.10nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK a...More data for this Ligand-Target Pair
In DepthDetails
US Patent