BDBM28337 (1R,2S)-1-{[4-(4-chlorophenyl)benzene]({2-[4-(methoxycarbonyl)-1H-imidazol-1-yl]ethyl})sulfonamido}-2-phenylcyclopropane-1-carboxylic acid::CHEMBL448604::US10322143, Shiozaki Compound 1::sulfonylamino-alkanecarboxylate, 51

SMILES COC(=O)c1cn(CCN([C@@]2(C[C@H]2c2ccccc2)C(O)=O)S(=O)(=O)c2ccc(cc2)-c2ccc(Cl)cc2)cn1

InChI Key InChIKey=CSUSVRGINZAUKG-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 28337   

LigandPNGBDBM28337((1R,2S)-1-{[4-(4-chlorophenyl)benzene]({2-[4-(meth...)
Affinity DataIC50: 73nMAssay Description:The ADAMTS-5 (Aggrecanase-2) assay was performed using fluorescent peptide substrate WAAG-3R and the recombinant Agg-2 pre-incubated with various con...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetA disintegrin and metalloproteinase with thrombospondin motifs 5(Human)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM28337((1R,2S)-1-{[4-(4-chlorophenyl)benzene]({2-[4-(meth...)
Affinity DataIC50: 73nMAssay Description:Inhibition of ADAMTS5More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetA disintegrin and metalloproteinase with thrombospondin motifs 5(Human)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM28337((1R,2S)-1-{[4-(4-chlorophenyl)benzene]({2-[4-(meth...)
Affinity DataIC50: 73nMAssay Description:Protein concentrations were measured using the Micro BCA Protein Assay Kit (Pierce/Thermo Scientific, IL). Sample buffer was mixed with 5-25 μg ...More data for this Ligand-Target Pair
In DepthDetails
US Patent