BDBM281765 9-(2-acryloyl-1,2,3,4- tetrahydroisoquinolin- 5-yl)-8-chloro-2,3,4,5- tetrahydro-1H- pyrido[4,3-b]indole-6- carboxamide::US10023534, Example 33

SMILES NC(=O)c1cc(Cl)c(-c2cccc3CN(CCc23)C(=O)C=C)c2c3CNCCc3[nH]c12

InChI Key InChIKey=RPQRKYCRCCLRPZ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 281765   

TargetTyrosine-protein kinase BTK(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM281765(9-(2-acryloyl-1,2,3,4- tetrahydroisoquinolin- 5-yl...)
Affinity DataIC50: 2.30nMpH: 7.4 T: 2°CAssay Description:To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 μM), A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
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