BDBM281748 4-(2-Acryloyl-1,2,3,4-tetrahydroisoquinolin-5-yl)-3-fluoro-7-(trifluoromethyl)-9H-carbazole-1-carboxamide (Single Enantiomeric Atropisomer)::US10023534, Example 7

SMILES NC(=O)c1cc(F)c(-c2cccc3CN(CCc23)C(=O)C=C)c2c3ccc(cc3[nH]c12)C(F)(F)F

InChI Key InChIKey=JPHVYOOIBQSKQD-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 281748   

TargetTyrosine-protein kinase BTK(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM281748(4-(2-Acryloyl-1,2,3,4-tetrahydroisoquinolin-5-yl)-...)
Affinity DataIC50: 0.180nMpH: 7.4 T: 2°CAssay Description:To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 μM), A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
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