BDBM281741 3-(4-Chloro-3-{[(3R)-2-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}phenyl)-3-cyclopropyl-2-methylpropanoic acid (diastereomer mixture)::US10023528, Example 30::US10259776, Example 30

SMILES CC(C(C1CC1)c1ccc(Cl)c(NC(=O)C([C@@H](C)C(F)(F)F)c2ccc(Cl)cc2)c1)C(O)=O

InChI Key InChIKey=JREAOVRWLWRZOU-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 281741   

TargetGuanylate cyclase soluble subunit alpha-1(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM281741(3-(4-Chloro-3-{[(3R)-2-chlorophenyl)-4,4,4-trifluo...)
Affinity DataEC50:  640nMpH: 7.5 T: 2°CAssay Description:To carry out the assay, 29 μl of enzyme solution [0-10 nM soluble guanylate cyclase (prepared according to H nicka et al, J. Mol. Med. 77, 14-23...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
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TargetGuanylate cyclase soluble subunit alpha-1(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM281741(3-(4-Chloro-3-{[(3R)-2-chlorophenyl)-4,4,4-trifluo...)
Affinity DataEC50:  640nMAssay Description:Soluble guanylate cyclase (sGC) converts on stimulation GTP into cGMP and pyrophosphate (PPi). PPi is detected with the aid of the assay described be...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
Go to US Patent