BDBM281741 3-(4-Chloro-3-{[(3R)-2-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}phenyl)-3-cyclopropyl-2-methylpropanoic acid (diastereomer mixture)::US10023528, Example 30::US10259776, Example 30
SMILES CC(C(C1CC1)c1ccc(Cl)c(NC(=O)C([C@@H](C)C(F)(F)F)c2ccc(Cl)cc2)c1)C(O)=O
InChI Key InChIKey=JREAOVRWLWRZOU-UHFFFAOYSA-N
Data 2 EC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 281741
Affinity DataEC50: 640nMpH: 7.5 T: 2°CAssay Description:To carry out the assay, 29 μl of enzyme solution [0-10 nM soluble guanylate cyclase (prepared according to H nicka et al, J. Mol. Med. 77, 14-23...More data for this Ligand-Target Pair
Affinity DataEC50: 640nMAssay Description:Soluble guanylate cyclase (sGC) converts on stimulation GTP into cGMP and pyrophosphate (PPi). PPi is detected with the aid of the assay described be...More data for this Ligand-Target Pair