BDBM281732 US10023528, Example 5::US10023528, Example 6::US10259776, Example 6

SMILES C[C@H]([C@H](C(=O)Nc1cc(ccc1Cl)C(C)(CC(O)=O)C1CCC1)c1ccc(Cl)cc1)C(F)(F)F

InChI Key InChIKey=BTOVIWFUGBHYGN-UHFFFAOYSA-N

Data  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 281732   

TargetGuanylate cyclase soluble subunit alpha-1(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM281732(US10023528, Example 5 | US10023528, Example 6 | US...)
Affinity DataEC50:  5.20nMpH: 7.5 T: 2°CAssay Description:To carry out the assay, 29 μl of enzyme solution [0-10 nM soluble guanylate cyclase (prepared according to H nicka et al, J. Mol. Med. 77, 14-23...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
Go to US Patent

TargetGuanylate cyclase soluble subunit alpha-1(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM281732(US10023528, Example 5 | US10023528, Example 6 | US...)
Affinity DataEC50:  56nMpH: 7.5 T: 2°CAssay Description:To carry out the assay, 29 μl of enzyme solution [0-10 nM soluble guanylate cyclase (prepared according to H nicka et al, J. Mol. Med. 77, 14-23...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
Go to US Patent

TargetGuanylate cyclase soluble subunit alpha-1(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM281732(US10023528, Example 5 | US10023528, Example 6 | US...)
Affinity DataEC50:  5.20nMAssay Description:Soluble guanylate cyclase (sGC) converts on stimulation GTP into cGMP and pyrophosphate (PPi). PPi is detected with the aid of the assay described be...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
Go to US Patent

TargetGuanylate cyclase soluble subunit alpha-1(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM281732(US10023528, Example 5 | US10023528, Example 6 | US...)
Affinity DataEC50:  56nMAssay Description:Soluble guanylate cyclase (sGC) converts on stimulation GTP into cGMP and pyrophosphate (PPi). PPi is detected with the aid of the assay described be...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
Go to US Patent