BDBM28122 3-cyanoquinoline, 7::6-methoxy-4-({4-[(1-methyl-1H-imidazol-2-yl)sulfanyl]phenyl}amino)-7-[3-(morpholin-4-yl)propoxy]quinoline-3-carbonitrile::CHEMBL322857

SMILES COc1cc2c(Nc3ccc(Sc4nccn4C)cc3)c(cnc2cc1OCCCN1CCOCC1)C#N

InChI Key InChIKey=LJLWBEHPUCOZAE-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 28122   

TargetInsulin-like growth factor 1 receptor(Human)
Wyeth Research

LigandPNGBDBM28122(6-methoxy-4-({4-[(1-methyl-1H-imidazol-2-yl)sulfan...)
Affinity DataIC50: 1.00E+3nMAssay Description:Assays were performed in microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified kinase in the presence of test com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2009
Entry Details Article
PubMed
LigandPNGBDBM28122(6-methoxy-4-({4-[(1-methyl-1H-imidazol-2-yl)sulfan...)
Affinity DataIC50: 5nMAssay Description:Inhibitory concentration against Mitogen activated protein kinase kinase kinase 1 was determined using Raf/MEK1 coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed