BDBM28118 3-cyanoquinoline, 3::4-({3-chloro-4-[(1-methyl-1H-imidazol-2-yl)sulfanyl]phenyl}amino)-7-[3-(4-ethylpiperazin-1-yl)propoxy]-6-methoxyquinoline-3-carbonitrile::CHEMBL103045

SMILES CCN1CCN(CCCOc2cc3ncc(C#N)c(Nc4ccc(Sc5nccn5C)c(Cl)c4)c3cc2OC)CC1

InChI Key InChIKey=AXHWESODWDIJCC-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 28118   

TargetInsulin-like growth factor 1 receptor(Human)
Wyeth Research

LigandPNGBDBM28118(CHEMBL103045 | 4-({3-chloro-4-[(1-methyl-1H-imidaz...)
Affinity DataIC50: 50nMAssay Description:Assays were performed in microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified kinase in the presence of test com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2009
Entry Details Article
PubMed
LigandPNGBDBM28118(CHEMBL103045 | 4-({3-chloro-4-[(1-methyl-1H-imidaz...)
Affinity DataIC50: 3nMAssay Description:Inhibitory concentration against Mitogen activated protein kinase kinase kinase 1 was determined using Raf/MEK1 coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM28118(CHEMBL103045 | 4-({3-chloro-4-[(1-methyl-1H-imidaz...)
Affinity DataIC50: 3nMAssay Description:Inhibition of MEK1 by raf/MEK1/MAPK coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed