BDBM281138 US10022354, Example 78

SMILES CC(C)c1cc([nH]n1)C(=O)N1CCC(C1)c1cc(cc(C)n1)-c1cnn(C)c1

InChI Key InChIKey=LNMSTPSCCSYARO-UHFFFAOYSA-N

Data  14 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 281138   

TargetLysine-specific demethylase 5A(Human)
Genentech

US Patent
LigandPNGBDBM281138(US10022354, Example 78)
Affinity DataIC50: 0.340nMpH: 7.0 T: 2°CAssay Description:Full length KDM5A enzyme was expressed and purified inhouse. Biotin-H3K4me3 peptide was purchased from New England Biolabs. HTRF reagents (containing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
Go to US Patent

TargetLysine-specific demethylase 2B(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM281138(US10022354, Example 78)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged KDM2B expressed in baculovirus infected Sf9 insect cells using H3K36me2 peptide as substrate a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2019
Entry Details Article
PubMed
TargetLysine-specific demethylase 3B(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM281138(US10022354, Example 78)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged KDM3B expressed in baculovirus infected Sf9 insect cells using H3K9me1 peptide as substrate af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2019
Entry Details Article
PubMed
TargetLysine-specific demethylase 6A(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM281138(US10022354, Example 78)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged KDM6A expressed in baculovirus infected Sf9 insect cells using H3K27me3 peptide as substrate a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2019
Entry Details Article
PubMed
TargetLysine-specific demethylase 5A(Human)
Genentech

US Patent
LigandPNGBDBM281138(US10022354, Example 78)
Affinity DataEC50: >3.00E+4nMAssay Description:Inhibition of KDM5A in human PC9 cells assessed as increase in H3K4me3 level after 5 days by mass-spectrometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2019
Entry Details Article
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM281138(US10022354, Example 78)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of KDM1A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2019
Entry Details Article
PubMed
TargetLysine-specific demethylase 4C(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM281138(US10022354, Example 78)
Affinity DataIC50: 1.33E+4nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged KDM4C expressed in baculovirus infected Sf9 insect cells using H3K9me3 peptide as substrate af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2019
Entry Details Article
PubMed
TargetHistone lysine demethylase PHF8(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM281138(US10022354, Example 78)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged KDM7B expressed in baculovirus infected Sf9 insect cells using H3K9me1 peptide as substrate af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2019
Entry Details Article
PubMed
TargetLysine-specific demethylase 5A(Human)
Genentech

US Patent
LigandPNGBDBM281138(US10022354, Example 78)
Affinity DataIC50: 260nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged KDM5A expressed in baculovirus infected Sf9 insect cells using H3K4me3 peptide as substrate af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2019
Entry Details Article
PubMed
TargetLysine-specific demethylase 5A(Human)
Genentech

US Patent
LigandPNGBDBM281138(US10022354, Example 78)
Affinity DataIC50: 260nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged KDM5A expressed in baculovirus infected Sf9 insect cells using H3K4me3 peptide as substrate af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2019
Entry Details Article
PubMed
TargetLysine-specific demethylase 5A(Human)
Genentech

US Patent
LigandPNGBDBM281138(US10022354, Example 78)
Affinity DataIC50: 770nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged KDM5A expressed in baculovirus infected Sf9 insect cells using H3K4me3 peptide as substrate af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2019
Entry Details Article
PubMed
TargetLysine-specific demethylase 5A(Human)
Genentech

US Patent
LigandPNGBDBM281138(US10022354, Example 78)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of KDM5A in human PC9 cells assessed as increase in H3K4me3 level after 5 days by mass-spectrometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2019
Entry Details Article
PubMed
TargetLysine-specific demethylase 4C(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM281138(US10022354, Example 78)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged KDM4C expressed in baculovirus infected Sf9 insect cells using H3K9me3 peptide as substrate af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2019
Entry Details Article
PubMed
TargetLysine-specific demethylase 5A(Human)
Genentech

US Patent
LigandPNGBDBM281138(US10022354, Example 78)
Affinity DataIC50: 260nMAssay Description:Inhibition of KDM5A (unknown origin ) by Alphascreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetLysine-specific demethylase 5A(Human)
Genentech

US Patent
LigandPNGBDBM281138(US10022354, Example 78)
Affinity DataIC50: 260nMAssay Description:Inhibition of KDM5A (unknown origin ) demethylase activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed