BDBM28042 5-[4-(4-phenylphenoxy)thieno[2,3-c]pyridin-2-yl]-1H-1,2,3,4-tetrazole::CHEMBL496536::thieno[2,3-c]pyridine, 7

SMILES O(c1ccc(cc1)-c1ccccc1)c1cncc2sc(cc12)-c1nnn[nH]1

InChI Key InChIKey=ALSCJHCBHMRCIE-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 28042   

TargetMitogen-activated protein kinase kinase kinase 8(Human)
Abbott Laboratories

LigandPNGBDBM28042(5-[4-(4-phenylphenoxy)thieno[2,3-c]pyridin-2-yl]-1...)
Affinity DataIC50: 130nMpH: 7.5 T: 2°CAssay Description:The COT direct HTRF assay was carried out using biotin-MEK1 as a substrate. The reaction was carried out in black 96 half-well plates. At designated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 8(Human)
Abbott Laboratories

LigandPNGBDBM28042(5-[4-(4-phenylphenoxy)thieno[2,3-c]pyridin-2-yl]-1...)
Affinity DataIC50: 150nMAssay Description:Inhibition of human recombinant COT by HTRF-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM28042(5-[4-(4-phenylphenoxy)thieno[2,3-c]pyridin-2-yl]-1...)
Affinity DataIC50: 9.70E+3nMAssay Description:Inhibition of MEK1 by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 8(Human)
Abbott Laboratories

LigandPNGBDBM28042(5-[4-(4-phenylphenoxy)thieno[2,3-c]pyridin-2-yl]-1...)
Affinity DataIC50: 4.30E+3nMAssay Description:Inhibition of COT by cell-based HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed