BDBM280363 2-(3-fluoropyridin-2-yl)-5-(propan-2-yl)-N-{1H-pyrrolo[2,3-b]pyridin-4-yl}pyridin-4-amine::US10030004, Compound 29::US10501436, Compound 29::US11053216, Compound 29::US11702401, Compound 29

SMILES CC(C)c1cnc(cc1Nc1ccnc2[nH]ccc12)-c1ncccc1F

InChI Key InChIKey=OCJCDFHRNVHPGQ-UHFFFAOYSA-N

Data  24 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 24 hits for monomerid = 280363   

TargetSerine/threonine-protein kinase receptor R3(Human)
Medivation Technologies

US Patent
LigandPNGBDBM280363(2-(3-fluoropyridin-2-yl)-5-(propan-2-yl)-N-{1H-pyr...)
Affinity DataIC50: 8.20E+3nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBone morphogenetic protein receptor type-1B(Human)
Medivation Technologies

US Patent
LigandPNGBDBM280363(2-(3-fluoropyridin-2-yl)-5-(propan-2-yl)-N-{1H-pyr...)
Affinity DataIC50: 1.53E+4nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTGF-beta receptor type-1(Human)
Medivation Technologies

US Patent
LigandPNGBDBM280363(2-(3-fluoropyridin-2-yl)-5-(propan-2-yl)-N-{1H-pyr...)
Affinity DataIC50: 16.4nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetActivin receptor type-1B(Human)
Medivation Technologies

US Patent
LigandPNGBDBM280363(2-(3-fluoropyridin-2-yl)-5-(propan-2-yl)-N-{1H-pyr...)
Affinity DataIC50: 10.5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBone morphogenetic protein receptor type-1A(Human)
Medivation Technologies

US Patent
LigandPNGBDBM280363(2-(3-fluoropyridin-2-yl)-5-(propan-2-yl)-N-{1H-pyr...)
Affinity DataIC50: 1.00E+4nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetActivin receptor type-1(Human)
Medivation Technologies

US Patent
LigandPNGBDBM280363(2-(3-fluoropyridin-2-yl)-5-(propan-2-yl)-N-{1H-pyr...)
Affinity DataIC50: 6.06E+4nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase receptor R3(Human)
Medivation Technologies

US Patent
LigandPNGBDBM280363(2-(3-fluoropyridin-2-yl)-5-(propan-2-yl)-N-{1H-pyr...)
Affinity DataIC50: 8.20E+3nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBone morphogenetic protein 10(Human)
Medivation Technologies

US Patent
LigandPNGBDBM280363(2-(3-fluoropyridin-2-yl)-5-(propan-2-yl)-N-{1H-pyr...)
Affinity DataIC50: 1.53E+4nMMore data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTGF-beta receptor type-1(Human)
Medivation Technologies

US Patent
LigandPNGBDBM280363(2-(3-fluoropyridin-2-yl)-5-(propan-2-yl)-N-{1H-pyr...)
Affinity DataIC50: 16.4nMMore data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetActivin receptor type-1B(Human)
Medivation Technologies

US Patent
LigandPNGBDBM280363(2-(3-fluoropyridin-2-yl)-5-(propan-2-yl)-N-{1H-pyr...)
Affinity DataIC50: 10.5nMMore data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBone morphogenetic protein receptor type-1A(Human)
Medivation Technologies

US Patent
LigandPNGBDBM280363(2-(3-fluoropyridin-2-yl)-5-(propan-2-yl)-N-{1H-pyr...)
Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetActivin receptor type-1(Human)
Medivation Technologies

US Patent
LigandPNGBDBM280363(2-(3-fluoropyridin-2-yl)-5-(propan-2-yl)-N-{1H-pyr...)
Affinity DataIC50: 6.06E+4nMMore data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase receptor R3(Human)
Medivation Technologies

US Patent
LigandPNGBDBM280363(2-(3-fluoropyridin-2-yl)-5-(propan-2-yl)-N-{1H-pyr...)
Affinity DataIC50: 8.20E+3nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBone morphogenetic protein receptor type-1B(Human)
Medivation Technologies

US Patent
LigandPNGBDBM280363(2-(3-fluoropyridin-2-yl)-5-(propan-2-yl)-N-{1H-pyr...)
Affinity DataIC50: 1.53E+4nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTGF-beta receptor type-1(Human)
Medivation Technologies

US Patent
LigandPNGBDBM280363(2-(3-fluoropyridin-2-yl)-5-(propan-2-yl)-N-{1H-pyr...)
Affinity DataIC50: 16.4nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetActivin receptor type-1B(Human)
Medivation Technologies

US Patent
LigandPNGBDBM280363(2-(3-fluoropyridin-2-yl)-5-(propan-2-yl)-N-{1H-pyr...)
Affinity DataIC50: 10.5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBone morphogenetic protein receptor type-1A(Human)
Medivation Technologies

US Patent
LigandPNGBDBM280363(2-(3-fluoropyridin-2-yl)-5-(propan-2-yl)-N-{1H-pyr...)
Affinity DataIC50: 1.00E+4nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetActivin receptor type-1(Human)
Medivation Technologies

US Patent
LigandPNGBDBM280363(2-(3-fluoropyridin-2-yl)-5-(propan-2-yl)-N-{1H-pyr...)
Affinity DataIC50: 6.06E+4nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase receptor R3(Human)
Medivation Technologies

US Patent
LigandPNGBDBM280363(2-(3-fluoropyridin-2-yl)-5-(propan-2-yl)-N-{1H-pyr...)
Affinity DataIC50: 8.20E+3nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBone morphogenetic protein receptor type-1B(Mouse)
Medivation Technologies

US Patent
LigandPNGBDBM280363(2-(3-fluoropyridin-2-yl)-5-(propan-2-yl)-N-{1H-pyr...)
Affinity DataIC50: 1.53E+4nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTGF-beta receptor type-1(Human)
Medivation Technologies

US Patent
LigandPNGBDBM280363(2-(3-fluoropyridin-2-yl)-5-(propan-2-yl)-N-{1H-pyr...)
Affinity DataIC50: 16.4nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetActivin receptor type-1B(Human)
Medivation Technologies

US Patent
LigandPNGBDBM280363(2-(3-fluoropyridin-2-yl)-5-(propan-2-yl)-N-{1H-pyr...)
Affinity DataIC50: 10.5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBone morphogenetic protein receptor type-1A(Human)
Medivation Technologies

US Patent
LigandPNGBDBM280363(2-(3-fluoropyridin-2-yl)-5-(propan-2-yl)-N-{1H-pyr...)
Affinity DataIC50: 1.00E+4nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetActivin receptor type-1(Human)
Medivation Technologies

US Patent
LigandPNGBDBM280363(2-(3-fluoropyridin-2-yl)-5-(propan-2-yl)-N-{1H-pyr...)
Affinity DataIC50: 6.06E+4nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair
In DepthDetails
US Patent