BDBM280361 4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropenyl-4-pyridyl]amino]-N-cyclopropyl-pyridine-3-carboxamide::US10030004, Compound 27::US10501436, Compound 27::US11053216, Compound 27::US11702401, Compound 27

SMILES CC(=C)c1cnc(cc1Nc1ccncc1C(=O)NC1CC1)-c1cc(Cl)ccc1F

InChI Key InChIKey=NRNOAZUAWDMPFI-UHFFFAOYSA-N

Data  24 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 24 hits for monomerid = 280361   

TargetSerine/threonine-protein kinase receptor R3(Human)
Medivation Technologies

US Patent

LigandBDBM280361(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropenyl-4-p...)Copy SMILESCopy InChI

Affinity DataIC50: 1.31E+4nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails
Copy BDB DOIUS Patent

Copy reaction URL

TargetBone morphogenetic protein receptor type-1B(Human)
Medivation Technologies

US Patent

LigandBDBM280361(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropenyl-4-p...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails
Copy BDB DOIUS Patent

Copy reaction URL

TargetTGF-beta receptor type-1(Human)
Medivation Technologies

US Patent

LigandBDBM280361(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropenyl-4-p...)Copy SMILESCopy InChI

Affinity DataIC50: 28.1nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails
Copy BDB DOIUS Patent

Copy reaction URL

TargetActivin receptor type-1B(Human)
Medivation Technologies

US Patent

LigandBDBM280361(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropenyl-4-p...)Copy SMILESCopy InChI

Affinity DataIC50: 40.2nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails
Copy BDB DOIUS Patent

Copy reaction URL

TargetBone morphogenetic protein receptor type-1A(Human)
Medivation Technologies

US Patent

LigandBDBM280361(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropenyl-4-p...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails
Copy BDB DOIUS Patent

Copy reaction URL

TargetActivin receptor type-1(Human)
Medivation Technologies

US Patent

LigandBDBM280361(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropenyl-4-p...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails
Copy BDB DOIUS Patent

Copy reaction URL

TargetSerine/threonine-protein kinase receptor R3(Human)
Medivation Technologies

US Patent

LigandBDBM280361(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropenyl-4-p...)Copy SMILESCopy InChI

Affinity DataIC50: 1.31E+4nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails
Copy BDB DOIUS Patent

Copy reaction URL

TargetBone morphogenetic protein 10(Human)
Medivation Technologies

US Patent

LigandBDBM280361(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropenyl-4-p...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails
Copy BDB DOIUS Patent

Copy reaction URL

TargetTGF-beta receptor type-1(Human)
Medivation Technologies

US Patent

LigandBDBM280361(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropenyl-4-p...)Copy SMILESCopy InChI

Affinity DataIC50: 28.1nMMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails
Copy BDB DOIUS Patent

Copy reaction URL

TargetActivin receptor type-1B(Human)
Medivation Technologies

US Patent

LigandBDBM280361(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropenyl-4-p...)Copy SMILESCopy InChI

Affinity DataIC50: 40.2nMMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails
Copy BDB DOIUS Patent

Copy reaction URL

TargetBone morphogenetic protein receptor type-1A(Human)
Medivation Technologies

US Patent

LigandBDBM280361(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropenyl-4-p...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails
Copy BDB DOIUS Patent

Copy reaction URL

TargetActivin receptor type-1(Human)
Medivation Technologies

US Patent

LigandBDBM280361(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropenyl-4-p...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails
Copy BDB DOIUS Patent

Copy reaction URL

TargetSerine/threonine-protein kinase receptor R3(Human)
Medivation Technologies

US Patent

LigandBDBM280361(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropenyl-4-p...)Copy SMILESCopy InChI

Affinity DataIC50: 1.31E+4nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails
Copy BDB DOIUS Patent

Copy reaction URL

TargetBone morphogenetic protein receptor type-1B(Human)
Medivation Technologies

US Patent

LigandBDBM280361(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropenyl-4-p...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails
Copy BDB DOIUS Patent

Copy reaction URL

TargetTGF-beta receptor type-1(Human)
Medivation Technologies

US Patent

LigandBDBM280361(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropenyl-4-p...)Copy SMILESCopy InChI

Affinity DataIC50: 28.1nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails
Copy BDB DOIUS Patent

Copy reaction URL

TargetActivin receptor type-1B(Human)
Medivation Technologies

US Patent

LigandBDBM280361(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropenyl-4-p...)Copy SMILESCopy InChI

Affinity DataIC50: 40.2nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails
Copy BDB DOIUS Patent

Copy reaction URL

TargetBone morphogenetic protein receptor type-1A(Human)
Medivation Technologies

US Patent

LigandBDBM280361(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropenyl-4-p...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails
Copy BDB DOIUS Patent

Copy reaction URL

TargetActivin receptor type-1(Human)
Medivation Technologies

US Patent

LigandBDBM280361(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropenyl-4-p...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails
Copy BDB DOIUS Patent

Copy reaction URL

TargetSerine/threonine-protein kinase receptor R3(Human)
Medivation Technologies

US Patent

LigandBDBM280361(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropenyl-4-p...)Copy SMILESCopy InChI

Affinity DataIC50: 1.31E+4nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails
Copy BDB DOIUS Patent

Copy reaction URL

TargetBone morphogenetic protein receptor type-1B(Mouse)
Medivation Technologies

US Patent

LigandBDBM280361(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropenyl-4-p...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails
Copy BDB DOIUS Patent

Copy reaction URL

TargetTGF-beta receptor type-1(Human)
Medivation Technologies

US Patent

LigandBDBM280361(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropenyl-4-p...)Copy SMILESCopy InChI

Affinity DataIC50: 28.1nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails
Copy BDB DOIUS Patent

Copy reaction URL

TargetActivin receptor type-1B(Human)
Medivation Technologies

US Patent

LigandBDBM280361(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropenyl-4-p...)Copy SMILESCopy InChI

Affinity DataIC50: 40.2nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails
Copy BDB DOIUS Patent

Copy reaction URL

TargetBone morphogenetic protein receptor type-1A(Human)
Medivation Technologies

US Patent

LigandBDBM280361(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropenyl-4-p...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails
Copy BDB DOIUS Patent

Copy reaction URL

TargetActivin receptor type-1(Human)
Medivation Technologies

US Patent

LigandBDBM280361(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropenyl-4-p...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails
Copy BDB DOIUS Patent

Copy reaction URL