BDBM280355 4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyridyl]amino]-N-[2-hydroxy-1-(hydroxymethyl)ethyl]pyridine-3-carboxamide::US10030004, Compound 22::US10501436, Compound 22::US11053216, Compound 22::US11702401, Compound 22

SMILES CC(C)c1cnc(cc1Nc1ccncc1C(=O)NC(CO)CO)-c1cc(Cl)ccc1F

InChI Key InChIKey=IPBLCOKXDQHSQW-UHFFFAOYSA-N

Data  30 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 30 hits for monomerid = 280355   

TargetActivin receptor type-1B(Human)
Medivation Technologies

US Patent
LigandPNGBDBM280355(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)
Affinity DataIC50: 56.7nMMore data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTGF-beta receptor type-1(Human)
Integral Biosciences

Curated by ChEMBL
LigandPNGBDBM280355(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)
Affinity DataIC50: 24nMAssay Description:Inhibition of human ALK5 autophosphorylationMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSerine/threonine-protein kinase receptor R3(Human)
Integral Biosciences

Curated by ChEMBL
LigandPNGBDBM280355(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)
Affinity DataIC50: 7.29E+3nMAssay Description:Inhibition of ALK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetActivin receptor type-1(Human)
Integral Biosciences

Curated by ChEMBL
LigandPNGBDBM280355(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of ALK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetActivin receptor type-1B(Human)
Medivation Technologies

US Patent
LigandPNGBDBM280355(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)
Affinity DataIC50: 57nMAssay Description:Inhibition of ALK4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetBone morphogenetic protein receptor type-1A(Human)
Integral Biosciences

Curated by ChEMBL
LigandPNGBDBM280355(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of ALK3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetBone morphogenetic protein receptor type-1B(Human)
Integral Biosciences

Curated by ChEMBL
LigandPNGBDBM280355(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of ALK6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetBone morphogenetic protein receptor type-1B(Human)
Integral Biosciences

Curated by ChEMBL
LigandPNGBDBM280355(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)
Affinity DataIC50: 1.00E+6nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTGF-beta receptor type-1(Human)
Integral Biosciences

Curated by ChEMBL
LigandPNGBDBM280355(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)
Affinity DataIC50: 24.7nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetActivin receptor type-1B(Human)
Medivation Technologies

US Patent
LigandPNGBDBM280355(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)
Affinity DataIC50: 56.7nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBone morphogenetic protein receptor type-1A(Human)
Integral Biosciences

Curated by ChEMBL
LigandPNGBDBM280355(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)
Affinity DataIC50: 1.00E+6nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetActivin receptor type-1(Human)
Integral Biosciences

Curated by ChEMBL
LigandPNGBDBM280355(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)
Affinity DataIC50: 1.00E+6nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase receptor R3(Human)
Integral Biosciences

Curated by ChEMBL
LigandPNGBDBM280355(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)
Affinity DataIC50: 7.29E+3nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBone morphogenetic protein 10(Human)
Medivation Technologies

US Patent
LigandPNGBDBM280355(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)
Affinity DataIC50: 1.00E+6nMMore data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTGF-beta receptor type-1(Human)
Integral Biosciences

Curated by ChEMBL
LigandPNGBDBM280355(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)
Affinity DataIC50: 24.7nMMore data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase receptor R3(Human)
Integral Biosciences

Curated by ChEMBL
LigandPNGBDBM280355(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)
Affinity DataIC50: 7.29E+3nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBone morphogenetic protein receptor type-1A(Human)
Integral Biosciences

Curated by ChEMBL
LigandPNGBDBM280355(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)
Affinity DataIC50: 1.00E+6nMMore data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetActivin receptor type-1(Human)
Integral Biosciences

Curated by ChEMBL
LigandPNGBDBM280355(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)
Affinity DataIC50: 1.00E+6nMMore data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase receptor R3(Human)
Integral Biosciences

Curated by ChEMBL
LigandPNGBDBM280355(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)
Affinity DataIC50: 7.29E+3nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBone morphogenetic protein receptor type-1B(Human)
Integral Biosciences

Curated by ChEMBL
LigandPNGBDBM280355(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)
Affinity DataIC50: 1.00E+6nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTGF-beta receptor type-1(Human)
Integral Biosciences

Curated by ChEMBL
LigandPNGBDBM280355(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)
Affinity DataIC50: 24.7nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetActivin receptor type-1B(Human)
Medivation Technologies

US Patent
LigandPNGBDBM280355(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)
Affinity DataIC50: 56.7nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBone morphogenetic protein receptor type-1A(Human)
Integral Biosciences

Curated by ChEMBL
LigandPNGBDBM280355(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)
Affinity DataIC50: 1.00E+6nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetActivin receptor type-1(Human)
Integral Biosciences

Curated by ChEMBL
LigandPNGBDBM280355(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)
Affinity DataIC50: 1.00E+6nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase receptor R3(Human)
Integral Biosciences

Curated by ChEMBL
LigandPNGBDBM280355(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)
Affinity DataIC50: 7.29E+3nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBone morphogenetic protein receptor type-1B(Mouse)
Medivation Technologies

US Patent
LigandPNGBDBM280355(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)
Affinity DataIC50: 1.00E+6nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTGF-beta receptor type-1(Human)
Integral Biosciences

Curated by ChEMBL
LigandPNGBDBM280355(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)
Affinity DataIC50: 24.7nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetActivin receptor type-1B(Human)
Medivation Technologies

US Patent
LigandPNGBDBM280355(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)
Affinity DataIC50: 56.7nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBone morphogenetic protein receptor type-1A(Human)
Integral Biosciences

Curated by ChEMBL
LigandPNGBDBM280355(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)
Affinity DataIC50: 1.00E+6nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetActivin receptor type-1(Human)
Integral Biosciences

Curated by ChEMBL
LigandPNGBDBM280355(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)
Affinity DataIC50: 1.00E+6nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair
In DepthDetails
US Patent