BDBM280342 4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropenyl-4-pyridyl]amino]-N-(2-hydroxy-1-methyl-ethyl)pyridine-3-carboxamide::US10030004, Compound 7b::US11053216, Compound 7b

SMILES C[C@H](CO)NC(=O)c1cnccc1Nc1cc(ncc1C(C)=C)-c1cc(Cl)ccc1F

InChI Key InChIKey=XMGRGPZCVNKAOK-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 280342   

TargetSerine/threonine-protein kinase receptor R3(Human)
Medivation Technologies

US Patent
LigandPNGBDBM280342(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropenyl-4-p...)
Affinity DataIC50: 1.65E+4nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2018
Entry Details
Go to US Patent

TargetActivin receptor type-1(Human)
Medivation Technologies

US Patent
LigandPNGBDBM280342(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropenyl-4-p...)
Affinity DataIC50: 1.00E+5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2018
Entry Details
Go to US Patent

TargetBone morphogenetic protein receptor type-1A(Human)
Medivation Technologies

US Patent
LigandPNGBDBM280342(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropenyl-4-p...)
Affinity DataIC50: 1.00E+5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2018
Entry Details
Go to US Patent

TargetActivin receptor type-1B(Human)
Medivation Technologies

US Patent
LigandPNGBDBM280342(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropenyl-4-p...)
Affinity DataIC50: 171nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2018
Entry Details
Go to US Patent

TargetTGF-beta receptor type-1(Human)
Medivation Technologies

US Patent
LigandPNGBDBM280342(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropenyl-4-p...)
Affinity DataIC50: 53.9nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2018
Entry Details
Go to US Patent

TargetBone morphogenetic protein receptor type-1B(Mouse)
Medivation Technologies

US Patent
LigandPNGBDBM280342(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropenyl-4-p...)
Affinity DataIC50: 1.00E+5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2018
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase receptor R3(Human)
Medivation Technologies

US Patent
LigandPNGBDBM280342(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropenyl-4-p...)
Affinity DataIC50: 1.65E+4nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2022
Entry Details
Go to US Patent

TargetActivin receptor type-1(Human)
Medivation Technologies

US Patent
LigandPNGBDBM280342(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropenyl-4-p...)
Affinity DataIC50: 1.00E+5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2022
Entry Details
Go to US Patent

TargetBone morphogenetic protein receptor type-1A(Human)
Medivation Technologies

US Patent
LigandPNGBDBM280342(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropenyl-4-p...)
Affinity DataIC50: 1.00E+5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2022
Entry Details
Go to US Patent

TargetActivin receptor type-1B(Human)
Medivation Technologies

US Patent
LigandPNGBDBM280342(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropenyl-4-p...)
Affinity DataIC50: 171nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2022
Entry Details
Go to US Patent

TargetTGF-beta receptor type-1(Human)
Medivation Technologies

US Patent
LigandPNGBDBM280342(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropenyl-4-p...)
Affinity DataIC50: 53.9nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2022
Entry Details
Go to US Patent

TargetBone morphogenetic protein 10(Human)
Medivation Technologies

US Patent
LigandPNGBDBM280342(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropenyl-4-p...)
Affinity DataIC50: 1.00E+5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2022
Entry Details
Go to US Patent