BDBM27961 3-(2-benzyl-1H-1,3-benzodiazol-6-yl)-1-[4-(morpholin-4-yl)cyclohexyl]-1H-pyrazolo[3,4-d]pyrimidin-4-amine::3-(2-benzyl-1H-benzo[d]imidazol-5-yl)-1-((1r,4r)-4-morpholinocyclohexyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine::3-(2-benzyl-1H-benzo[d]imidazol-6-yl)-1-((trans)-4-morpholinocyclohexyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine::CHEMBL249496::substituted benzimidazole, 6

SMILES Nc1ncnc2n(nc(-c3ccc4nc(Cc5ccccc5)[nH]c4c3)c12)[C@H]1CC[C@@H](CC1)N1CCOCC1

InChI Key InChIKey=MSLPPMUTXCBVLE-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 27961   

TargetInsulin-like growth factor 1 receptor(Human)
Abbott Laboratories

LigandPNGBDBM27961(3-(2-benzyl-1H-benzo[d]imidazol-6-yl)-1-((trans)-4...)
Affinity DataIC50: 64nMpH: 7.5 T: 2°CAssay Description:Assays were performed in 96-well microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified kinase in the presence of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/5/2009
Entry Details Article
PubMed
LigandPNGBDBM27961(3-(2-benzyl-1H-benzo[d]imidazol-6-yl)-1-((trans)-4...)
Affinity DataIC50: 270nMpH: 7.5 T: 2°CAssay Description:Assays were performed in 96-well microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified kinase in the presence of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/5/2009
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Abbott Laboratories

LigandPNGBDBM27961(3-(2-benzyl-1H-benzo[d]imidazol-6-yl)-1-((trans)-4...)
Affinity DataIC50: 186nMpH: 7.5 T: 2°CAssay Description:Assays were performed in 96-well microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified kinase in the presence of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/5/2009
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Abbott Laboratories

LigandPNGBDBM27961(3-(2-benzyl-1H-benzo[d]imidazol-6-yl)-1-((trans)-4...)
Affinity DataIC50: 94nMAssay Description:Inhibition IGF1R phosphorylation in human MiaPaCa2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Abbott Laboratories

LigandPNGBDBM27961(3-(2-benzyl-1H-benzo[d]imidazol-6-yl)-1-((trans)-4...)
Affinity DataIC50: 64nMAssay Description:Inhibition of human IGF1R expressed in Sf21 cells by time-resolved fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed