BDBM279104 3-methyl-1-[1-methylpropyl]-5-(2-propoxy-3-pyridyl)-N-(1H-pyrazol-3-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine,enantiomer 2::US10034861, Example 135::US10512632, Example 135::US10766893, Example S135::US10806718, Example 135::US11491140, Example 135::US11634416, Example 135

SMILES CCCOc1ncccc1-c1cc(NCc2cc[nH]n2)c2n(nc(C)c2n1)C(C)CC

InChI Key InChIKey=QYAONCSFRJZQFJ-UHFFFAOYSA-N

Data  18 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 279104   

LigandPNGBDBM279104(3-methyl-1-[1-methylpropyl]-5-(2-propoxy-3-pyridyl...)
Affinity DataIC50: 1.90nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
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LigandPNGBDBM279104(3-methyl-1-[1-methylpropyl]-5-(2-propoxy-3-pyridyl...)
Affinity DataIC50: 3.60nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
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LigandPNGBDBM279104(3-methyl-1-[1-methylpropyl]-5-(2-propoxy-3-pyridyl...)
Affinity DataIC50: 0.0950nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
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LigandPNGBDBM279104(3-methyl-1-[1-methylpropyl]-5-(2-propoxy-3-pyridyl...)
Affinity DataIC50: 1.90nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
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LigandPNGBDBM279104(3-methyl-1-[1-methylpropyl]-5-(2-propoxy-3-pyridyl...)
Affinity DataIC50: 3.60nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/20/2023
Entry Details
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LigandPNGBDBM279104(3-methyl-1-[1-methylpropyl]-5-(2-propoxy-3-pyridyl...)
Affinity DataIC50: 0.0950nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/20/2023
Entry Details
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LigandPNGBDBM279104(3-methyl-1-[1-methylpropyl]-5-(2-propoxy-3-pyridyl...)
Affinity DataIC50: 1.90nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/20/2023
Entry Details
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LigandPNGBDBM279104(3-methyl-1-[1-methylpropyl]-5-(2-propoxy-3-pyridyl...)
Affinity DataIC50: 3.60nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
Go to US Patent

LigandPNGBDBM279104(3-methyl-1-[1-methylpropyl]-5-(2-propoxy-3-pyridyl...)
Affinity DataIC50: 0.0950nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
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LigandPNGBDBM279104(3-methyl-1-[1-methylpropyl]-5-(2-propoxy-3-pyridyl...)
Affinity DataIC50: 1.90nMpH: 7.6 T: 2°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2018
Entry Details
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LigandPNGBDBM279104(3-methyl-1-[1-methylpropyl]-5-(2-propoxy-3-pyridyl...)
Affinity DataIC50: 3.60nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2021
Entry Details
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LigandPNGBDBM279104(3-methyl-1-[1-methylpropyl]-5-(2-propoxy-3-pyridyl...)
Affinity DataIC50: 0.0950nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2021
Entry Details
Go to US Patent

LigandPNGBDBM279104(3-methyl-1-[1-methylpropyl]-5-(2-propoxy-3-pyridyl...)
Affinity DataIC50: 1.90nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2021
Entry Details
Go to US Patent

LigandPNGBDBM279104(3-methyl-1-[1-methylpropyl]-5-(2-propoxy-3-pyridyl...)
Affinity DataIC50: 3.60nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2020
Entry Details
Go to US Patent

LigandPNGBDBM279104(3-methyl-1-[1-methylpropyl]-5-(2-propoxy-3-pyridyl...)
Affinity DataIC50: 0.0950nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2020
Entry Details
Go to US Patent

LigandPNGBDBM279104(3-methyl-1-[1-methylpropyl]-5-(2-propoxy-3-pyridyl...)
Affinity DataIC50: 1.90nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2020
Entry Details
Go to US Patent

LigandPNGBDBM279104(3-methyl-1-[1-methylpropyl]-5-(2-propoxy-3-pyridyl...)
Affinity DataIC50: 3.60nMpH: 7.6 T: 2°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2018
Entry Details
Go to US Patent

LigandPNGBDBM279104(3-methyl-1-[1-methylpropyl]-5-(2-propoxy-3-pyridyl...)
Affinity DataIC50: 0.0950nMpH: 7.6 T: 2°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2018
Entry Details
Go to US Patent