BDBM278809 2-[(3R)- or (3S)- azepan-3- ylamino]-N-(2- cyanophenyl)pyrrolo [1,2- b]pyridazine-7- carboxamide trifluoroacetate::US10040798, Example 109

SMILES O=C(Nc1ccccc1C#N)c1ccc2ccc(N[C@H]3CCCCNC3)nn12

InChI Key InChIKey=WROMRGAVHVAQJW-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 278809   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM278809(2-[(3R)- or (3S)- azepan-3- ylamino]-N-(2- cyanoph...)
Affinity DataIC50: 7nMpH: 7.2Assay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
In DepthDetails
US Patent