BDBM278774 2-{[(1R,2S)-2- aminocyclohexyl]amino}- N-[4- (difluoromethyl)thiophen- 3-yl]pyrrolo[1,2- b]pyridazine-7- carboxamide trifluoroacetate::US10040798, Example 72

SMILES OC(=O)C(F)(F)F.N[C@H]1CCCC[C@H]1Nc1ccc2ccc(C(=O)Nc3cscc3C(F)F)n2n1

InChI Key InChIKey=QQPXRDREIOMSTH-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 278774   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM278774(2-{[(1R,2S)-2- aminocyclohexyl]amino}- N-[4- (difl...)
Affinity DataIC50: 24nMpH: 7.2Assay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
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US Patent