BDBM278716 2-[(3R)-3- aminopiperidin-1-yl]-N- [3-(difluoromethyl)-1- methyl-1H-pyrazol-4- yl]pyrrolo[1,2- b]pyridazine-7- carboxamide trifluoroacetate::US10040798, Example 13

SMILES OC(=O)C(F)(F)F.Cn1cc(NC(=O)c2ccc3ccc(nn23)N2CCC[C@@H](N)C2)c(n1)C(F)F

InChI Key InChIKey=IWEZKMVDXNGVFC-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 278716   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM278716(2-[(3R)-3- aminopiperidin-1-yl]-N- [3-(difluoromet...)
Affinity DataIC50: 0.5nMpH: 7.2Assay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
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US Patent