BDBM278467 (2S)-2-(azetidin-1-yl)-2-(3-methoxyphenyl)-N-[5-[[(3R)-1-pyridazin-3-ylpyrrolidin-3-yl]amino]-1,3,4-thiadiazol-2-yl]acetamide and (2R)-2-(azetidin-1-yl)-2-(3-methoxyphenyl)-N-[5-[[(3R)-1-pyridazin-3-ylpyrrolidin-3-yl]amino]-1,3,4-thiadiazol-2-yl]acetamide::US10040789, Example 6(a)::US10040789, Example 6(b)

SMILES COc1cccc(c1)[C@H](N1CCC1)C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1

InChI Key InChIKey=VOPBRZXKPSPMAY-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 278467   

TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandPNGBDBM278467((2S)-2-(azetidin-1-yl)-2-(3-methoxyphenyl)-N-[5-[[...)
Affinity DataIC50: 981nMpH: 7.8 T: 2°CAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandPNGBDBM278467((2S)-2-(azetidin-1-yl)-2-(3-methoxyphenyl)-N-[5-[[...)
Affinity DataIC50: 944nMpH: 7.8 T: 2°CAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In DepthDetails
US Patent