BDBM278427 US10040788, Example 18(b)::US10040788, Example 20(b)

SMILES CO[C@H](C(=O)Nc1nnc(N[C@H]2CCN(C2)c2cccnn2)s1)c1ccccc1

InChI Key InChIKey=KLQLQDLJJUAEGT-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 278427   

TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandPNGBDBM278427(US10040788, Example 20(b) | US10040788, Example 18...)
Affinity DataIC50: 107nMpH: 7.8Assay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2018
Entry Details
Go to US Patent

TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandPNGBDBM278427(US10040788, Example 20(b) | US10040788, Example 18...)
Affinity DataIC50: 119nMpH: 7.8Assay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2018
Entry Details
Go to US Patent