BDBM276559 2-[[1-[3-(Difluoromethoxy)-4-fluoro-phenyl]triazol-4-yl]methoxy]-4-::US10071988, Example 499::US10233173, Example 499

SMILES COCc1ccnc(OCc2cn(nn2)-c2ccc(F)c(OC(F)F)c2)n1

InChI Key InChIKey=BZQOGTTUTCCEIL-UHFFFAOYSA-N

Data  1 KI  13 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 276559   

TargetRetinoic acid receptor RXR-alpha(Human)
Janssen Pharmaceutica

US Patent

LigandBDBM276559(US10071988, Example 499 | 2-[[1-[3-(Difluoromethox...)Copy SMILESCopy InChI

Affinity DataIC50: 16nMpH: 7.4 T: 2°CAssay Description:NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...More data for this Ligand-Target Pair

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Date in BDB:
12/21/2018
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TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Janssen Pharmaceutica

US Patent

LigandBDBM276559(US10071988, Example 499 | 2-[[1-[3-(Difluoromethox...)Copy SMILESCopy InChI

Affinity DataIC50: 16nMAssay Description:NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...More data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Date in BDB:
12/27/2019
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TargetGlutamate receptor ionotropic, NMDA 2A(Human)
Janssen Research & Development

Curated by ChEMBL

LigandBDBM276559(US10071988, Example 499 | 2-[[1-[3-(Difluoromethox...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human GluN2A receptor by FLIPR assayMore data for this Ligand-Target Pair

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Date in BDB:
12/13/2024
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TargetGlutamate receptor ionotropic, NMDA 2C(Human)
Janssen Research & Development

Curated by ChEMBL

LigandBDBM276559(US10071988, Example 499 | 2-[[1-[3-(Difluoromethox...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human GluN2C receptor by FLIPR assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Date in BDB:
12/13/2024
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TargetGlutamate receptor ionotropic, NMDA 2D(Human)
Janssen Research & Development

Curated by ChEMBL

LigandBDBM276559(US10071988, Example 499 | 2-[[1-[3-(Difluoromethox...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human GluN2D receptor by FLIPR assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
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Date in BDB:
12/13/2024
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TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Janssen Research & Development

Curated by ChEMBL

LigandBDBM276559(US10071988, Example 499 | 2-[[1-[3-(Difluoromethox...)Copy SMILESCopy InChI

Affinity DataIC50: 16nMAssay Description:Negative allosteric modulation of human GluN1A/GluN2B receptor expressed in T-REX-CHO cells preincubated for 5 mins followed by glutamate and glycine...More data for this Ligand-Target Pair

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Date in BDB:
12/13/2024
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TargetPotassium voltage-gated channel subfamily H member 2(Human)
Janssen Research & Development

Curated by ChEMBL

LigandBDBM276559(US10071988, Example 499 | 2-[[1-[3-(Difluoromethox...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of [3H]dofetilide from human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProtUniProtKB/TrEMBL
GoogleScholar

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Date in BDB:
12/13/2024
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TargetCytochrome P450 1A2(Human)
Janssen Research & Development

Curated by ChEMBL

LigandBDBM276559(US10071988, Example 499 | 2-[[1-[3-(Difluoromethox...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes incubated for 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair

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Date in BDB:
12/13/2024
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TargetCytochrome P450 2C19(Human)
Janssen Research & Development

Curated by ChEMBL

LigandBDBM276559(US10071988, Example 499 | 2-[[1-[3-(Difluoromethox...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes incubated for 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Date in BDB:
12/13/2024
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TargetCytochrome P450 2C8(Human)
Janssen Research & Development

Curated by ChEMBL

LigandBDBM276559(US10071988, Example 499 | 2-[[1-[3-(Difluoromethox...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C8 in human liver microsomes incubated for 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Date in BDB:
12/13/2024
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TargetCytochrome P450 2C9(Human)
Janssen Research & Development

Curated by ChEMBL

LigandBDBM276559(US10071988, Example 499 | 2-[[1-[3-(Difluoromethox...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes incubated for 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Date in BDB:
12/13/2024
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TargetCytochrome P450 2D6(Human)
Janssen Research & Development

Curated by ChEMBL

LigandBDBM276559(US10071988, Example 499 | 2-[[1-[3-(Difluoromethox...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes incubated for 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProtUniProtKB/TrEMBL
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
12/13/2024
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TargetCytochrome P450 3A4(Human)
Janssen Research & Development

Curated by ChEMBL

LigandBDBM276559(US10071988, Example 499 | 2-[[1-[3-(Difluoromethox...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes incubated for 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProtUniProtKB/TrEMBL
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
12/13/2024
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TargetGlutamate receptor ionotropic, NMDA 2B(Rat)
Janssen Research & Development

Curated by ChEMBL

LigandBDBM276559(US10071988, Example 499 | 2-[[1-[3-(Difluoromethox...)Copy SMILESCopy InChI

Affinity DataKi:  32nMAssay Description:Displacement of 3-(3H) 1-(azetidin-1-yl)-2-(6- (4-fluoro-3-methyl-phenyl)pyrrolo-(3,2-6) pyridin-1yl)ethanone from GluN2B receptor in rat cortical me...More data for this Ligand-Target Pair

Target InfoPDB
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Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
12/13/2024
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