BDBM276042 2-[5-[2-(cyclopropylmethoxy)-4-fluorophenyl]-1-methylimidazol-4-yl]-4-(1H-triazol-4-yl)pyridine::US10071984, Example 4::US10174003, Example 4::US9896436, Example 4

SMILES Cn1cnc(c1-c1ccc(F)cc1OCC1CC1)-c1cc(ccn1)-c1c[nH]nn1

InChI Key InChIKey=VAPWXZBGJQGXNZ-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 276042   

TargetLysine-specific demethylase 2B(Human)
Celgene Quanticel Research

US Patent
LigandPNGBDBM276042(2-[5-[2-(cyclopropylmethoxy)-4-fluorophenyl]-1-met...)
Affinity DataIC50: 100nMT: 2°CAssay Description:The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
Go to US Patent

TargetLysine-specific demethylase 2A(Human)
Celgene Quanticel Research

US Patent
LigandPNGBDBM276042(2-[5-[2-(cyclopropylmethoxy)-4-fluorophenyl]-1-met...)
Affinity DataIC50: 100nMT: 2°CAssay Description:The ability of test compounds to inhibit the activity of FBXL11 was determined in 384-well plate format under the following reaction conditions: 0.15...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
Go to US Patent

TargetIsoform 2 of Histone lysine demethylase PHF8 (2)(Human)
Celgene Quanticel Research

US Patent
LigandPNGBDBM276042(2-[5-[2-(cyclopropylmethoxy)-4-fluorophenyl]-1-met...)
Affinity DataIC50: 5.50E+3nMT: 2°CAssay Description:The ability of test compounds to inhibit the activity of PHF8 was determined in 384-well plate format under the following reaction conditions: 3 nM P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
Go to US Patent

TargetLysine-specific demethylase 2B(Human)
Celgene Quanticel Research

US Patent
LigandPNGBDBM276042(2-[5-[2-(cyclopropylmethoxy)-4-fluorophenyl]-1-met...)
Affinity DataIC50: 100nMAssay Description:The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

TargetLysine-specific demethylase 2A(Human)
Celgene Quanticel Research

US Patent
LigandPNGBDBM276042(2-[5-[2-(cyclopropylmethoxy)-4-fluorophenyl]-1-met...)
Affinity DataIC50: 100nMAssay Description:PHF8 Assay: The ability of test compounds to inhibit the activity of PHF8 was determined in 384-well plate format under the following reaction condit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

TargetHistone lysine demethylase PHF8(Human)
Celgene Quanticel Research

US Patent
LigandPNGBDBM276042(2-[5-[2-(cyclopropylmethoxy)-4-fluorophenyl]-1-met...)
Affinity DataIC50: 500nMAssay Description:PHF8 Assay: The ability of test compounds to inhibit the activity of PHF8 was determined in 384-well plate format under the following reaction condit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent