BDBM274958 US9556190, Example 46

SMILES C[C@@H]1OC(=O)c2c1ccnc2N(C)[C@@H]1CC[C@@H](C)N(C1)C(=O)c1ccccc1-n1nccn1

InChI Key InChIKey=QLFJRMDPVABIGY-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 274958   

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM274958(US9556190, Example 46)
Affinity DataIC50: 28nMAssay Description: In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
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TargetOrexin/Hypocretin receptor type 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM274958(US9556190, Example 46)
Affinity DataIC50: 1.00E+4nMAssay Description: In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
Go to US Patent