BDBM274952 1,1-dimethyl-4- ({(3R,6R)-6-methyl- 1-[(2-pyrimidin-2- ylphenyl)carbonyl]- piperidin-3- yl}amino)furo[3,4- c]pyridin-3(1H)- one::US9556190, Example 42

SMILES C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-c1ncccn1)Nc1nccc2c1C(=O)OC2(C)C

InChI Key InChIKey=ROHXLMQNGHESKG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 274952   

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM274952(1,1-dimethyl-4- ({(3R,6R)-6-methyl- 1-[(2-pyrimidi...)
Affinity DataIC50: 26nMAssay Description: In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
Go to US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM274952(1,1-dimethyl-4- ({(3R,6R)-6-methyl- 1-[(2-pyrimidi...)
Affinity DataIC50: 2.86E+3nMAssay Description: In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
Go to US Patent