BDBM274935 1,1-dimethyl-4-(((3R,6R)-6-methyl-1- (2-(pyrimidin-2-yl)thiophene-3- carbonyl)piperidin-3-yl)oxy)furo[3,4- c]pyridin-3(1H)-one::US9556190, Example 25

SMILES C[C@@H]1CC[C@H](CN1C(=O)c1ccsc1-c1ncccn1)Oc1nccc2c1C(=O)OC2(C)C

InChI Key InChIKey=XEDDWCANFOZZHV-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 274935   

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM274935(1,1-dimethyl-4-(((3R,6R)-6-methyl-1- (2-(pyrimidin...)
Affinity DataIC50: 44nMAssay Description: In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
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TargetOrexin/Hypocretin receptor type 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM274935(1,1-dimethyl-4-(((3R,6R)-6-methyl-1- (2-(pyrimidin...)
Affinity DataIC50: 9.11E+3nMAssay Description: In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
Go to US Patent